Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Inner Structure of Cells Behaves Much as Molten Glass

21.06.2005


Finding may impact understanding of mechanical facets of many diseases



An international team led by Jeffrey J. Fredberg, professor of bioengineering and physiology at the Harvard School of Public Health, has found that the cell modulates its mechanical properties in much the same way as a glassblower shapes fine glassware. This new view of cellular functions sheds light on mechanical facets of phenomena as diverse as asthma, cancer, inflammation, and vascular disease. These findings appear in advance online from the July, 2005 issue of Nature Materials.

To fashion a work of glass, a glassblower must heat the object, shape it, and then cool it down. Fredberg and his colleagues have shown that the cell modulates its mechanical properties and changes its malleability in much the same way. But instead of changing temperature, the cell changes a temperature-like property that has much the same effect.


Using an array of novel nanotechnologies developed by the researchers at HSPH, Fredberg et al. discovered the basic physical laws that describe cell mechanical behavior. Previously, the classical model of cell mechanical behavior had pictured the cell as a viscous fluid core contained by an elastic cortical membrane, but their findings did not at all conform to that picture. The team’s experiments show that the cell is a strange intermediate form of matter that is neither solid nor fluid, but retains features of both. Moreover, as the cell goes about its routine business of stretching, spreading, and contracting, it can vary that temperature-like property and control where it sits along the spectrum between solid-like and fluid-like states.

"These findings have important lessons for understanding the dynamics of structural proteins at a scale that is intermediate between the single molecule and integrative cellular function. This is a collective phenomenon of many molecules interacting in concert, and would disappear altogether in the study of one molecule interacting with another in isolation," said Fredberg. He continued, "The laws governing cell behavior bring together into one physical picture cell elasticity, viscosity, and remodeling, and give us a different way to think about the molecular basis of airway narrowing in asthma, vessel narrowing in vascular disease, wound repair, embryonic development, and cell invasion in cancer, all of which have important mechanical components. Perhaps most surprising of all, in addition to offering a different way to think about mechanisms of disease, these findings shed light upon the behavior of familiar inert condensed substances that remain poorly understood, including pastes, foams, emulsions, and granular materials."

The research was supported by grants from the National Institutes of Health.

Contact:
Christina Roache
(617) 432-6052
677 Huntington Avenue
Boston, MA 02115

Christina Roache | EurekAlert!
Further information:
http://www.nature.com/nmat/index.html
http://www.hsph.harvard.edu

More articles from Life Sciences:

nachricht 'Y' a protein unicorn might matter in glaucoma
23.10.2017 | Georgia Institute of Technology

nachricht Microfluidics probe 'cholesterol' of the oil industry
23.10.2017 | Rice University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Microfluidics probe 'cholesterol' of the oil industry

23.10.2017 | Life Sciences

Gamma rays will reach beyond the limits of light

23.10.2017 | Physics and Astronomy

The end of pneumonia? New vaccine offers hope

23.10.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>