ASK-chip shall enable targeted functional analysis of the human kinome
ProQinase, a division of KTB Tumorforschungs GmbH at the Tumor Biology Center, Freiburg, the NMI Natural and Medical Sciences Institute at the University of Tübingen, and Antibodies by Design, a division of MorphoSys AG, Munich, today announced the start of a joint project which could revolutionize the analysis of all human protein kinases - the human "kinome". The project combines the established protein kinase platform of ProQinase with the know-how of Antibodies by Design in the field of custom-made antibody generation and the experience of NMI with siRNA and Biochip technologies. The goal of the project is to develop an adenoviral siRNA-kinome-chip (ASK chip) which enables the parallel inhibition of all human protein kinases by means of RNA interference on a miniaturized Biochip. This technology allows simultaneous determination of the function of all protein kinases, e.g. growth of tumor cells to identify starting points for new therapies. Members of the protein kinase family are considered as promising targets for therapy of different diseases. In the coming three years, the project will be supported by approximately EUR 2.0 million within the scope of the BioChancePLUS Program of the German Federal Ministry of Research (BMBF).
More than 500 protein kinases, which pass on cell signals and affect almost all biological processes, are currently known. A number of these kinases are suspected to play a central role in various diseases such as cancer, inflammation, or cardiovascular disease. "Protein kinases function as a complex network which often is altered in human diseases, but can be affected therapeutically by drugs that block individual protein kinases", stated Dr. Michael Kubbutat, Head of Research & Development at ProQinase. "Until now, however, an overall picture and understanding of this network that would allow e.g. to determine the effects of drugs on the interaction of the protein kinase network is still missing. The expertise of ProQinase in this field will support this project to find a remedy."
Dr. Nadja Gugeler | idw
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