Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers discover molecular mechanism that desensitizes us to cold

28.04.2005


Findings demonstrate mechanism used by numerous membrane proteins throughout the body – opens pathway to new areas of exploration

Mount Sinai School of Medicine researchers have discovered how the membrane protein that allows us to sense cold works and how this protein becomes desensitized so that one no longer feels the cold. The study, published this week as an advance online publication by Nature Neuroscience, focused on a specific region of the cold receptor which is found in many other receptors, including ones involved in taste, vision and fertilization. Therefore, the findings may have important implications across a wide range of areas.

Diomedes Logothetis, PhD, Dean of the Mount Sinai Graduate School of Biological Sciences, post-doctoral fellow Tibor Rohacs and colleagues studied the receptor that is responsible for the sensation of cold. They found that a specific region of this receptor interacts with a signaling lipid in the cell membrane called PIP2. Cold or menthol stimulate this receptor and alter the electrical properties of the membrane, a process that leads to the sensation of cold. When the receptor is stimulated, calcium enters the cell and stimulates the breakdown of PIP2. When PIP2 is broken down, the receptor becomes inactive, thus ending the sensation or desensitizing the cell to the cold stimulus.



"This finding provides critical information to help us understand how we sense heat and cold and from that to expand our understanding of temperature regulation," said Dr. Logothetis. "Additionally, because the region of this receptor that interacts with PIP2 is found in many similar membrane proteins, we now have a new lead in investigating regulation of the many functions in which these proteins are involved."

Many signals, such as neurotransmitters and growth factors are known to catalyze the breakdown of PIP2. Now that researchers know how PIP2 interacts with this large class of membrane proteins, they can begin to look out how these signals work and what effects they are having in various areas of the body.

The Mount Sinai Press Office | EurekAlert!
Further information:
http://www.mssm.edu

More articles from Life Sciences:

nachricht Individual Receptors Caught at Work
19.10.2017 | Julius-Maximilians-Universität Würzburg

nachricht Rapid environmental change makes species more vulnerable to extinction
19.10.2017 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Electrode materials from the microwave oven

19.10.2017 | Materials Sciences

New material for digital memories of the future

19.10.2017 | Materials Sciences

Physics boosts artificial intelligence methods

19.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>