Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UT Southwestern lead site for study of a new multiple sclerosis drug

27.04.2005


UT Southwestern Medical Center is the lead research site testing a new treatment for a rare form of multiple sclerosis. Called "primary progressive," this type of MS affects about 15 percent of patients with the neurodegenerative disease. "There really hasn’t been a lot of research or treatment options for patients with this form of MS," said Dr. Kathleen Hawker, assistant professor of neurology, who is heading up the clinical investigation.



UT Southwestern researchers are testing Rituxan – a therapeutic monoclonal antibody approved by the Food and Drug Administration in 1997 for treating some forms of cancer. "It’s an exciting study and the patients are really enthusiastic about this," Dr. Hawker said.

The primary progressive form of MS is characterized by a slow, steady onset, usually beginning with walking difficulties and steadily worsening with motor dysfunctions and increased disability. People with primary progressive MS don’t respond as well to traditional drug therapies as patients with other, more common forms of the disease, such as relapsing and remitting MS. Because of this, many people with primary progressive MS have higher incidences of debilitating physical side effects. Many need walkers or wheelchairs. "Rituxan works on a component of the immune system called B-cells," Dr. Hawker said. "The drug depletes B-cells and has been used to treat other autoimmune diseases such as lupus."


As the lead testing site, UT Southwestern doctors in the MS Program and Clinical Center were involved in developing the protocol, choosing subsequent sites and overseeing the research. There are 61 sites in the United States and 11 in Canada currently working on the two-year trial. Total enrollment will be 435 people, with 15 at UT Southwestern.

Patients throughout the region are participating in the study, which still has openings available for those who meet the criteria. People with primary progressive MS usually are in their 40s or 50s, and men and women have an equal risk of developing the disease. Fewer brain lesions are present on a magnetic resonance imaging screening with this form of MS as well, making it more difficult to diagnose, Dr. Hawker said.

New patients in the study receive lab work, an electrocardiogram to check their heart, magnetic resonance imaging, spinal tap, and a physical and neurological exam prior to receiving the first dose of the drug.

Patients who can participate in this placebo-controlled study are given infusion treatments that take a full day. Dr. Hawker said positive outcomes for patients during the study would mark a breakthrough for treatment of primary progressive MS. For more information, call 214-648-6449.

Katherine Morales | EurekAlert!
Further information:
http://www.utsouthwestern.edu

More articles from Life Sciences:

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

Quantum optical sensor for the first time tested in space – with a laser system from Berlin

23.01.2017 | Physics and Astronomy

The interactome of infected neural cells reveals new therapeutic targets for Zika

23.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>