Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genetic changes in breast tissue caused by pregnancy hormone helps prevent breast cancer

20.04.2005


A full-term pregnancy at an early age is one of the most effective ways to reduce the lifetime risk of breast cancer, according to research pathologist Irma H. Russo, M.D., of Fox Chase Cancer Center in Philadelphia. A number of studies around the world have established that a full-term pregnancy by age 20 reduces breast cancer risk by half.



Previous studies by Russo and colleagues suggest that breast cells reach full maturity--a process called differentiation--only after a full-term pregnancy. Once this process is complete, the cells are less vulnerable to cancer-causing changes. An early pregnancy confers the strongest protection by limiting the time breast cells remain immature.

"A high-susceptibility or high-risk window exists early in life, between the start of ovarian function and the first pregnancy," explained Russo. "During this period, the mammary gland has continuously varying characteristics influenced by ovarian and pituitary hormones. These traits change during pregnancy under the influence of embryonic and placental hormones."


Russo’s laboratory has demonstrated that both pregnancy and a hormone produced during pregnancy, called human chorionic gonadotropin (hCG), inhibit breast cancer in rats. The placental hormone hCG promotes full maturation of breast cells and also wards off cancerous changes in these cells later.

"This led us to postulate that this hormone might be useful for breast cancer prevention in women," Russo said. "Toward this goal, we designed experiments to learn, first, whether the protection conferred by hCG results from genetic changes specific to this hormone and, second, whether a similar genomic signature would result from either pregnancy or ovarian steroid hormones. Richard Wang, Ph.D., a postdoctoral associate in Russo’s laboratory, presented the results of the first study Sunday, April 17 at the 96th Annual Meeting of the American Association for Cancer Research. The study used virgin rats treated with a daily hCG injection compared to untreated virgin rats.

"Our results show that hCG induces permanent genetic changes in the mammary gland that are related to its breast cancer prevention effect," said Wang.

In addition to Irma Russo, Wang’s Fox Chase co-authors include Jose Russo, M.D., director of Fox Chase’s Breast Cancer and the Environment Research Center; research associates Gabriela Balogh, Ph.D., and Fathima Sheriff, M.D.; research technicians Rachael L. Fernbaugh and Patricia A. Russo; and postdoctoral associates Daniel A. Mailo, Ph.D., and Raquel Moral, Ph.D.

The second study compared four groups of rats: a pregnant group, a virgin group treated with hCG, a virgin group treated with the hormones estrogen and progesterone (ovarian steroid hormones) and an untreated group. Daniel Mailo presented the results Tuesday, April 19 at the AACR meeting.

"These data show that both hCG and pregnancy induce permanent genetic changes that do not result from steroid hormones," Mailo said. Mailo’s co-authors include Irma and Jose Russo, Sheriff, Balogh and research technician Rebecca Heulings.

A grant from the National Institutes of Health supported both studies.

Colleen Kirsch | EurekAlert!
Further information:
http://www.fccc.edu

More articles from Life Sciences:

nachricht Warming ponds could accelerate climate change
21.02.2017 | University of Exeter

nachricht An alternative to opioids? Compound from marine snail is potent pain reliever
21.02.2017 | University of Utah

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>