Microscopes at microscopic size
Traditionally if scientists wanted to look at something small they would put a sample under a microscope but now researchers have managed to shrink the microscope itself to the size of a single human cell. An interdisciplinary research team, funded by the Biotechnology and Biological Science Research Council (BBSRC) and the Engineering and Physical Sciences Research Council (EPSRC) have developed optical biochips no larger than a single cell that could lead to faster development of new drugs and quicker medical tests.
The research team moved away from the idea that a microscope is something you have to look through to create optical biochips onto which scientists can place biological samples. Special fluorescent chemicals are then used together with tiny light emitting lasers to allow the scientists to analyse the cells or targets within the cells. Researchers can use this capability to examine cellular conditions for certain diseases or to develop new treatments by studying the way cells react to a drug.
The biochips also raise the possibility of a micro-laboratory, the size of a credit card, which would be able to perform medical diagnostics, improving patient treatment by reducing the number of hospital visits needed for tests.
The initial research has led to the creation of a spin-out company, BioStatus Ltd, supported by a BBSRC Small Business Research Initiative grant. BioStatus has developed the research to refine the fluorescent probe technology and also to make the analysis of biological samples more sophisticated.
Professor Paul Smith, the research group leader, said, "Our research and the outcomes from the spin-out company could help to revolutionise how we examine biological samples. Our next step will be to develop simple, small diagnostic devices. Future generations may be able to use these as the basis for hand-held systems that will be able to perform diagnostic functions in the field that currently require a laboratory test."
Professor Julia Goodfellow, Chief Executive of BBSRC, said, "The success of the research into biochips and the development of the science through the spin-out company shows how cutting edge research in the biosciences can meet real world challenges. Bochips have the potential to make a real difference in medical diagnostics and drug development."
The research is being carried out at the Wales College of Medicine and involves researchers at Cardiff University, University of Bangor, the Gray Cancer Institute in London and collaboration with the University of Warwick and laboratories in the United States.
Matt Goode | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...