Researchers identify potential therapeutic target for Huntingtons disease
Researchers studying yeast cells have identified a metabolic enzyme as a potential therapeutic target for treating Huntingtons disease, a fatal inherited neurodegenerative disorder for which there is currently no effective treatment. The group, whose results appear in the May issue of Nature Genetics, includes researchers from the University of Washington School of Medicine in Seattle and the University of Maryland School of Medicine in Baltimore. The paper was published online in advance at the journals Web site, http://www.nature.com/ng/index.html.
The group performed a genetic experiment known as a loss-of-function suppressor screen, which searches for genes that, when switched off, reduce the toxic effects of the mutant protein associated with Huntingtons. One of the genes they identified encodes an enzyme, called KMO, that has been previously implicated in the disease. The enzyme functions in a metabolic pathway that is activated at early stages of the disease in people with Huntingtons, as well as in animal models of the disease.
"The nice thing about this finding is that there is a chemical compound available that inhibits KMO activity," said Dr. Paul Muchowski, assistant professor of pharmacology at the UW, who led the study. "Were in the midst of testing that compound in a mouse model of Huntingtons disease."
Further support for KMO as a therapeutic target for Huntingtons disease comes from a recent study led by Dr. Aleksey G. Kazantsev of Harvard Medical School. In this study, researchers used cell-based experiments to screen about 20,000 chemical compounds, and identified one that suppresses neurodegeneration in a fly model of the disease. That compound has a very similar chemical structure as the drug that inhibits the target identified by Muchowskis group. The results appeared in the Jan. 18, 2005, issue of the Proceedings of the National Academy of Sciences.
In addition to finding a potential drug target for future Huntingtons treatment, the study by Muchowski and his colleagues could take research on the disease in a new direction: towards microglial cells, which are immune cells in the brain. Previous research has focused exclusively on neuronal cells, but the enzyme KMO is found predominantly in microglial cells. Since inhibiting KMO activity has a direct effect on toxicity of the mutant protein associated with Huntingtons, that could mean microgial cells are home to an important step in progression of the disease.
Huntingtons affects an estimated 30,000 people in the United States. It is characterized by loss of motor control and cognitive functions, as well as by depression or other psychiatric problems.
Justin Reedy | EurekAlert!
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