Gene is found in the chromosomal region that influences innate immunity to tuberculosis
Researchers from the Harvard School of Public Health studying tuberculosis resistance and susceptibility in animals have identified a gene in mice which plays a significant role in limiting the multiplication of intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes inside host cells. The gene, Intracellular pathogen resistance 1 (Ipr1), found in the chromosome location known as sst1 (super susceptibility to tuberculosis 1), turns on a regulated cell death pathway of the bacteria-infected cells causing apoptosis and prevents catastrophic cell death, or necrosis. The findings appear in a paper in the April 7, 2005 issue of the journal Nature.
It is estimated that 8 million people are infected with tuberculosis annually with approximately 2 million of those dying from the lung disease per year. Yet only about 10 percent of people infected actually develop tuberculosis. Stress, malnutrition and other environmental factors significantly influence an individuals susceptibility to developing the disease. In addition, genetic factors have been known to play an important role in determining outcomes of tuberculosis infection in human and other mammalian hosts. However, individual host resistance genes such as Ipr1, involved in innate immunity for tuberculosis, have been difficult to pinpoint, because of a highly complex multigenic control of host immunity.
Kevin C. Myron | EurekAlert!
BigH1 -- The key histone for male fertility
14.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)
Guardians of the Gate
14.12.2017 | Max-Planck-Institut für Biochemie
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
14.12.2017 | Health and Medicine
14.12.2017 | Physics and Astronomy
14.12.2017 | Life Sciences