The TIM23 complex, which regulates the transport of protein to the mitochondria in a cell, is much more complicated than was previously believed. This is shown by Uppsala University researcher Maria Lind in an article in the leading journal Cell.
Together with Agnieszka Chacinska from the University of Freiburg in Germany, Maria Lind from Uppsala University is lead author of the article in Cell.
Agnieszka Chacinska’s and her study shows how the TIM23 complex functions, something that was previously unknown. The TIM23 complex regulates the transport of protein to the mitochondria in the cell. The findings reveal that the TIM23 complex is highly complicated. It can transport proteins even though there is a tension between the two sides of the complex. “The complex opens only a single channel when the protein comes, in order not to disturb the negative or positive charge on the respective sides of the complex,” explains Maria Lind. “It is essential that the voltage created by the difference in the charges be maintained when the mitochondria are to produce energy.”
Anneli Waara | alfa
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