The protein Mnd2 inhibits premature separation of chromosomes during the formation of gametes. The now published discovery of this regulatory function may help to understand the origin of some common congenital chromosome defects. The project of a team of the University of Vienna funded by the Austrian Science Fund (FWF) contributes to the Campus Vienna Biocenter maintaining a top-level position in the field of cell division research.
During the division of somatic cells (mitosis) newly duplicated chromosomes (sister chromatids) separate and segregate to opposite daughter cells. The cell division, which leads to the formation of gametes (egg and sperm cells), serves a different purpose. In this cell division called meiosis, the two complete sets of chromosomes (maternal and paternal ones) in each body cell are reduced to a single one.
Prof. Franz Klein and his colleague, Ph.D. student Alexandra Penkner from the Department of Chromosome Biology of the Max Perutz Laboratories at the Campus Vienna Biocenter, have now published results on an important regulation of this process in the journal CELL. These findings show that the premature segregation of sister chromatids with lethal consequences are inhibited by a protein named Mnd2.
Prof. Franz Klein | alfa
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