Findings may yield methods for improving fertility as well as developing male contraceptives
For 40 percent of the estimated six million American couples battling infertility, the problem lies with the man. But help may be on the way. New research in mice by scientists at Rockefeller University and the Population Council sheds light on the causes behind male infertility. The findings, reported in the March issue of Developmental Cell, also include potential targets for developing a reversible male contraceptive.
"The sperm from these mice have problems similar to many defects seen in human sperm that contribute to infertility," says Hermann Steller, Ph.D., head of the Strang Laboratory of Apoptosis and Cancer Biology at Rockefeller. "We have found an event in the maturation of sperm that is extremely sensitive, and thus would be a good target for both improving fertility and quality of sperm for men who are infertile, and for the inhibition of fertility using a male contraceptive pill."
Kristine A. Kelly | EurekAlert!
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