Temple University researchers have developed a new drug that halts cancer cell division, instigating tumor death. The drug works by interfering with the activity of a gene called Plk1 and is now in phase I clinical trials for human cancer therapy. Their research is published in the March issue of Cancer Cell.
Plk1 is one of several molecules that play a critical role in the spread of cancer. Previous studies have found higher levels of Plk1 in cancer tumors and in patients with poorer survival rates. When Plk1 activity was blocked, cancer cells could not divide and tumors could not survive.
Lead by Prem Reddy, Ph.D., professor of biochemistry and director of the Fels Institute for Cancer Research at Temple University School of Medicine, the Temple team sought out a new compound that would target and block Plk1. They developed and tested ON01910, a small molecule that inhibits Plk1 activity, on 94 different human cancers.
Eryn Jelesiewicz | EurekAlert!
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Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
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