A new tumor-suppressor gene has been discovered by a team of researchers at Penn State, which also has discovered how the gene works with another tumor suppressor to control tissue growth. The teams genetic and biochemical studies will be published in the 11 March 2005 issue of the journal Cell. "This discovery extends our understanding of how tissue growth is controlled both during normal development and during the formation of tumors, and it raises the possibility that the function of this gene may have important implications for the understanding and treatment of human cancers," says research leader Zhi-Chun Lai, associate professor of biology, biochemistry, and molecular biology.
Lai has named the new gene "mats," an abbreviation for "Mob As Tumor Suppressor." As part of the research, Lais lab added a human mats gene to tumor-plagued flies known to have a genetic defect in their mats gene, then found that tumors no longer developed within this line of flies in individuals that had incorporated the human gene into their DNA. "When we introduced the human mats gene into the mutant flys body, we found it was able to perform the same function as a normal flys mats gene," Lai says.
The mats gene is thought to be present in all plants and animals, and Lais lab identified defective mats genes in a human skin-cancer tumor and in a mouse breast-cancer tumor. "In these tumors, we found that the mouse counterpart and the human counterpart of the mats gene were mutated. On the basis of our research, we speculate that all mats genes in animals and plants may regulate cell number and tissue growth by restricting the proliferation of cells and promoting their timely death," Lai says.
Barbara K. Kennedy | EurekAlert!
New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego
Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
16.01.2018 | Materials Sciences
16.01.2018 | Materials Sciences
16.01.2018 | Power and Electrical Engineering