The Biaffin GmbH & Co KG is one of nine European partners of a new EU "Specifically Targeted Research Project (STREP)" started on 1 st of January 2005 for a period of three years. The project is entitled "Function of small RNAs across kingdoms (FOSRAK)" to study the hitherto unrecognised cellular role of various classes of short non-coding RNAs in regulating gene expression in a variety of organisms across different biological kingdoms like eubacteria, protists, plants and animals.
The aim of this project is the advancement of knowledge of how these riboregulators and their interacting protein components are integrated into the general network of gene expression and in developmental processes. Little is known of how the short heterochromatic RNAs (sh RNAs) interact with chromatin, short interference RNAs (si RNAs) modulate mRNA stabiltity, micro RNAs (mi RNAs) influence the level of translation and small nucleolar RNAs (sno RNAs) are involved in postranscriptional modification of ribosomal and spliceosomal small nucleolar RNAs (sn RNAs). Small RNAs from pathogenic bacteria and human small RNAs that are implicated in human diseases and cancer formation are a special focus for future therapeutic intervention.
Biaffin provides the sophisticated instrumentation of surface plasmon resonance technology coupled to mass spectrometry (BIA-MS; BIA: biomolecular interaction analysis) to identify and kinetically characterise molecular targets of regulatory RNAs. To elucidate the mechanism of RNA interaction with their targets the structural and functional aspects of small regulatory RNAs has to be studied in detail. Innovation aspects will be created to use the BIA technology for studying RNA-RNA and RNA-protein interactions.
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
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24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy