Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New treatment options for some difficult cancers improve survival and quality of life

07.03.2005


Researchers at Wake Forest University Baptist Medical Center have shown that surgery combined with inserting heated chemotherapy drugs directly into the abdomen can improve survival rates and quality of life in patients with several cancers that historically have a poor prognosis.



Results of four separate studies are being presented at the Society of Oncology Surgeons national meeting March 3-5 in Atlanta. The types of cancer reported at the meeting that have been treated with a combination of surgery and intraperitoneal hyperthermic chemotherapy (IPHC) are tumors of the abdominal cavity that have spread from the appendix, small bowel and advanced ovarian cancer.

The technique is also useful for tumors that have spread from the colon, rectum, stomach as well as well as mesothelioma of the abdominal cavity. Peritoneal cancer -- cancer of the lining of the abdominal wall -- is a very common cause of death in patients with cancers in the abdomen. Surgery alone has proven to have limited effectiveness, as has radiation therapy and systemic chemotherapy. These new studies show that the combination of surgery and IPHC improves overall survival and quality of life in these selected patients. "Patients with peritoneal cancer that has spread from the small bowel represent both a unique diagnostic and treatment challenge," said Perry Shen, M.D., assistant professor of surgical oncology and lead author of one of the studies. Attempts to treat this cancer with systemic chemotherapy and conventional surgery have not been successful.


The patients in this study had a mean survival of 45.1 months, compared to 3.1 months for patients who received only traditional treatment. "While further study is needed on the effects of surgery and IPHC with other treatments," said Shen, "the data from this study suggest that this combination seems to be an effective and attractive option in a very difficult situation."

In a study of patients with tumors in the abdominal cavity which have spread from tumors of the appendix, data from John Stewart, M.D., instructor in surgery, show that long-term survival is anticipated in the majority of patients with low grade tumors who are treated with surgery and IPHC. High grade lesions result in significantly lower survival rates even with this treatment. High grade and low grade refer to the stage of malignancy.

A study of patients with advanced ovarian cancer showed that it is responsive to a combination of surgery and IPHC. The treatment plan could also include systemic chemotherapy. Additional IPHC treatment was feasible during subsequent reassessment surgery. "Surgery combined with IPHC seems to be a life extending and enhancing treatment option for patients with some of the most difficult cancers," said Edward Levine, MD, professor and head of surgical oncology at Wake Forest Baptist. The positive results of these studies support the need for further evaluation of the use of IPHC and surgery in the treatment of other metastatic cancers of the abdomen.

Jonnie Rohrer | EurekAlert!
Further information:
http://www.wfubmc.edu

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Supersensitive through quantum entanglement

28.06.2017 | Physics and Astronomy

X-ray photoelectron spectroscopy under real ambient pressure conditions

28.06.2017 | Physics and Astronomy

Mice provide insight into genetics of autism spectrum disorders

28.06.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>