Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCI researchers identify trigger for onset of Alzheimer’s, aiding search for new therapies

03.03.2005


Clearance of beta amyloid accumulation within neurons stops memory decline in mice



Researchers at UC Irvine have identified a trigger at the molecular level that marks the onset of memory decline in mice genetically engineered to develop brain lesions – in the form of plaques and tangles – associated with Alzheimer’s disease. The trigger is a protein called "beta amyloid" that accumulates within neurons in the mice’s brains. Although several researchers have studied the association between beta amyloid and memory, the UCI research team is the first to identify that early beta amyloid accumulation within neurons is the trigger for the onset of memory decline in Alzheimer’s.

"This finding has important and useful implications for the pharmaceutical industry in terms of developing drugs that can target beta amyloid as soon as it accumulates within the neurons," said Frank LaFerla, principal investigator of the research project, associate professor of neurobiology and behavior, and co-director of the UCI Institute for Brain Aging and Dementia. "Once the plaques and tangles form, it is too late."


The researchers report their findings in the March 3 issue of Neuron.

Although the production of beta amyloid occurs in all brains, healthy brains are able to clear away excess amounts. Brains with Alzheimer’s disease, on the other hand, are unable to control beta amyloid accumulation. In monitoring the mice from birth until six months, the researchers found that the mice had no Alzheimer’s disease symptoms at two months of age. At four months, however, the mice showed a decline in their long-term memory retention that the researchers found occurred in combination with the buildup of beta amyloid in neurons of the hippocampus, amygdala and cerebral cortex regions of the mice’s brains.

While the hippocampus is thought to play a key role in learning and memory formation, the amygdala is involved in computing the emotional significance of events. The cerebral cortex – the outer portion of the brain – is where thought processes occur. "It’s significant that the plaques and tangles did not show up in our mice at the four-month stage," said Lauren M. Billings, a postdoctoral researcher in the UCI School of Biological Sciences’ Department of Neurobiology and Behavior, and the first author of the study. "It suggests strongly that these hallmarks of Alzheimer’s disease contribute to cognitive decline only later and that the intraneuronal beta amyloid is the molecular trigger for the onset of this insidious disease."

Billings explained the mice were making more beta amyloid than their brains could clear naturally. When the researchers cleared away the beta amyloid within the neurons, however, they were able to correct the memory impairments in the mice. Moreover, the researchers found that a reemergence of beta amyloid inside the neurons in the mice marked again the onset of memory problems.

In their study, the researchers used mice that were genetically engineered to develop Alzheimer’s disease, a necessary step in the research since mice ordinarily do not develop symptoms of the disease. The molecular and cellular changes that trigger the onset of memory decline in the human brain with Alzheimer’s disease are currently unknown and constitute a difficult problem to address. Hence, researchers turn to animal models, such as mice.

The UCI researchers studied 270 mice from birth until six months. They placed the mice in a water maze set in a water tank where the mice were encouraged repeatedly to locate a hidden platform in the tank by making spatial associations in the room to facilitate their search. After the platform was removed, the researchers monitored in subsequent trials how fast the mice swam to where the platform used to be – an indication of how well the mice remembered the platform’s location. At four months of age, the mice developed memory problems together with beta amyloid accumulation in their brain’s neurons.

Alzheimer’s disease is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly in the United States, affecting 4.5-5 million adults – 10 times more than those affected by Parkinson’s disease. Starting with mild memory problems and ending with severe brain damage, Alzheimer’s usually begins after the age of 60, the risk increasing with age. If no effective therapies are developed, by 2050 it is estimated that 13 million Americans will have the disease. In the United States, five percent of the population over age 65 and one-third of the population over age 85 are afflicted by it. It is the third most expensive disease to treat and is the third leading cause of death, trailing cancer and coronary heart disease.

Iqbal Pittalwala | EurekAlert!
Further information:
http://www.uci.edu

More articles from Life Sciences:

nachricht Programming cells with computer-like logic
27.07.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht Identified the component that allows a lethal bacteria to spread resistance to antibiotics
27.07.2017 | Institute for Research in Biomedicine (IRB Barcelona)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Physicists Design Ultrafocused Pulses

Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.

Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

Programming cells with computer-like logic

27.07.2017 | Life Sciences

Identified the component that allows a lethal bacteria to spread resistance to antibiotics

27.07.2017 | Life Sciences

Malaria Already Endemic in the Mediterranean by the Roman Period

27.07.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>