Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Slight Fluorescence Gives Hope For Recovery

22.02.2005


Stomach ulcer not only aches, it also fluoresce. Russian researchers believe that the brighter the fluorescence is, the less chances the patient has to do without the operation.

Specialists of the Moscow Regional Scientific-Research Clinical Institute “MONIKI” named after M.F. Vladimirsky and the Chair of Biophysics, Russian State Medical University, have developed a fiber-optic spectrum analyzer that allows to measure intensity of fluorescence from the surface of the gastrointestinal tract ulcers in the course of laser therapy. Fluorescence intensity allows to foresee how successful the treatment would be and to select the most optimal irradiation conditions.

About 40 years ago, low intensity laser irradiation started to be applied for inflammatory diseases therapy. Multiple diseases are accompanied by increase of content of complex organic molecules – porphyrins – in the cells. These molecules are extremely sensitive to the red component of spectrum, therefore, the tissues with high content of porphyrins become targets to laser irradiation, which, in its turn, activates defense functions and the cell division process.



These effects account for therapeutic action of low-intensity laser irradiation: accelerated wound healing and inflammatory processes therapy. The tissues containing porphyrins glow upon irradiation, and fluorescence intensity depends on the quantity of porphyrins. The Moscow specialists compared the data on porphyrin content in the area of ulcer with the laser therapy efficiency.

All experiments were carried out in the “MONIKI” named after M.F. Vladimirsky on the basis of specially established laser diagnostics room. The helium-neon laser was used as radiation source. The group under observation included 192 patients with protractedly nonhealing ulcers. Each of the patients was provided with 7 to 10 laser therapy seances, in the course of them the researchers checked porphyrins’ efficiency and spectum of fluorescence on the surface of affected and healthy tissues adjacent to them.

To this end, during the scheduled endoscopic examination the spectrum analyzer optical fiber was passed through the biopsy canal and brought to the examined section.

With the majority of patients, fluorescence was distinctly noticeable in the area of ulcer even prior to the beginning of the course of treatment. Its spectrum has a typical shape and differs from the fluorescence spectrum when ulcer has already turned to cancer. As the patients undertook the laser therapy course, the signal weakened. With the recovered patients, the spectra of fluorescence from the area of pathology and from healthy tissues coincided by the end of the course.

Laser therapy is considered successful when the ulcer heals up completely and does not disturb the patient for at least three years. Unfortunately, this does not always happen. With some patients, relapses occur earlier, and sometimes physicians fail to cure ulser and the patients have to be forwarded to operation. It has turned out that the result of treatment is directly tied up with intensity of fluorescence of affected tissues. The more intense the fluorescence is, the less hope exists for successful laser cure of ulcer.

In other words, depending on the content of porphyrins in the wound (ulcer) material, laser irradiation causes either medicinal effect or overdosage effect. Apparently, the excess of porphyrins makes tissues not simply sensitive, but over-susceptible to laser action.

Probably, laser therapy could help such patients but commonly accepted radiation doses do not suit them. The optimal dose should be selected individually, and this can be done, according to researchers’ opinion, based on spectra of porphyrins’ fluorescence.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>