Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Slight Fluorescence Gives Hope For Recovery

22.02.2005


Stomach ulcer not only aches, it also fluoresce. Russian researchers believe that the brighter the fluorescence is, the less chances the patient has to do without the operation.

Specialists of the Moscow Regional Scientific-Research Clinical Institute “MONIKI” named after M.F. Vladimirsky and the Chair of Biophysics, Russian State Medical University, have developed a fiber-optic spectrum analyzer that allows to measure intensity of fluorescence from the surface of the gastrointestinal tract ulcers in the course of laser therapy. Fluorescence intensity allows to foresee how successful the treatment would be and to select the most optimal irradiation conditions.

About 40 years ago, low intensity laser irradiation started to be applied for inflammatory diseases therapy. Multiple diseases are accompanied by increase of content of complex organic molecules – porphyrins – in the cells. These molecules are extremely sensitive to the red component of spectrum, therefore, the tissues with high content of porphyrins become targets to laser irradiation, which, in its turn, activates defense functions and the cell division process.



These effects account for therapeutic action of low-intensity laser irradiation: accelerated wound healing and inflammatory processes therapy. The tissues containing porphyrins glow upon irradiation, and fluorescence intensity depends on the quantity of porphyrins. The Moscow specialists compared the data on porphyrin content in the area of ulcer with the laser therapy efficiency.

All experiments were carried out in the “MONIKI” named after M.F. Vladimirsky on the basis of specially established laser diagnostics room. The helium-neon laser was used as radiation source. The group under observation included 192 patients with protractedly nonhealing ulcers. Each of the patients was provided with 7 to 10 laser therapy seances, in the course of them the researchers checked porphyrins’ efficiency and spectum of fluorescence on the surface of affected and healthy tissues adjacent to them.

To this end, during the scheduled endoscopic examination the spectrum analyzer optical fiber was passed through the biopsy canal and brought to the examined section.

With the majority of patients, fluorescence was distinctly noticeable in the area of ulcer even prior to the beginning of the course of treatment. Its spectrum has a typical shape and differs from the fluorescence spectrum when ulcer has already turned to cancer. As the patients undertook the laser therapy course, the signal weakened. With the recovered patients, the spectra of fluorescence from the area of pathology and from healthy tissues coincided by the end of the course.

Laser therapy is considered successful when the ulcer heals up completely and does not disturb the patient for at least three years. Unfortunately, this does not always happen. With some patients, relapses occur earlier, and sometimes physicians fail to cure ulser and the patients have to be forwarded to operation. It has turned out that the result of treatment is directly tied up with intensity of fluorescence of affected tissues. The more intense the fluorescence is, the less hope exists for successful laser cure of ulcer.

In other words, depending on the content of porphyrins in the wound (ulcer) material, laser irradiation causes either medicinal effect or overdosage effect. Apparently, the excess of porphyrins makes tissues not simply sensitive, but over-susceptible to laser action.

Probably, laser therapy could help such patients but commonly accepted radiation doses do not suit them. The optimal dose should be selected individually, and this can be done, according to researchers’ opinion, based on spectra of porphyrins’ fluorescence.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Life Sciences:

nachricht For a chimpanzee, one good turn deserves another
27.06.2017 | Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPIMIS)

nachricht New method to rapidly map the 'social networks' of proteins
27.06.2017 | Salk Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Touch Displays WAY-AX and WAY-DX by WayCon

27.06.2017 | Power and Electrical Engineering

Drones that drive

27.06.2017 | Information Technology

Ultra-compact phase modulators based on graphene plasmons

27.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>