Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stat5 protein inhibits spread of breast cancer cells

04.02.2005


The presence of a protein known as Stat5 prevents laboratory-grown breast cancer cells from becoming invasive and aggressive, according to new research from Georgetown University. The research, which appears in the January 27 issue of Oncogene, could one day lead to advanced therapies for breast cancer patients.



"This new insight is significant because it is the invasive behavior of breast cancer cells that leads to the formation of metastatic cancer, the most advanced and serious form of the disease," said Hallgeir Rui, MD, PhD, associate professor of oncology, Lombardi Comprehensive Cancer Center at Georgetown University and principal investigator of the study.

The research, which was funded by the National Institutes of Health and the Department of Defense, showed that when Stat5 was active, breast cancer cells were not only less invasive, but also aggregated into clusters, resembling healthy breast cells. Conversely, loss of Stat5 stimulated invasive tumor cell activities.


"The apparent suppressive role of Stat5 in breast cancer is surprising in light of the tumor promoting role that Stat5 appears to play in leukemias, lymphomas, and prostate cancer," said Rui. "On the other hand, the new data may not be so unexpected since Stat5 is known to promote differentiation of healthy breast cells. Differentiation is a form of orderliness that is gradually lost as cancer cells become more aggressive and invasive."

Stat5 is a DNA-binding protein that regulates expression of certain genes, many of which remain unknown. During pregnancy, Stat5 is activated by the hormone prolactin, and stimulates milk production in the breast. In related research, Rui and colleagues have recently shown that Stat5 remains active in healthy breast cells in non-pregnant women. However, active Stat5 is lost in many breast cancers, especially as the tumors become more aggressive and metastatic.

Rui cautions that this research was done with cancer cells cultured in the laboratory and that additional studies are needed to determine whether Stat5 also inhibits invasion of human breast cancer cells tested in mice. These studies are underway and the outcome will determine whether new therapies could be designed to one day take advantage of the invasion-suppressive role of Stat5 in breast cancer. Because Stat5 is a protein that is located inside the cell, it cannot be administered in the form of injections to slow down breast tumor cells. However, Rui’s laboratory is exploring alternative ways of switching Stat5 back on in breast cancer.

The results of this study support related research done last year by Rui and his colleagues: In a study that was published in the June 1, 2004 issue of the Journal of Clinical Oncology, the team identified Stat5 as a biomarker of a type of breast cancer that is associated with a favorable prognosis in patients. In fact, in breast cancer patients whose tumors had not yet spread to the nearby lymph nodes, loss of Stat5 was associated with a nearly 7.5-fold increased risk of death from recurring breast cancer. The new research now provides a mechanism to explain why Stat5 may be a useful tumor marker to predict risk and outcome in early stage breast cancer patients.

Amy DeMaria | EurekAlert!
Further information:
http://www.georgetown.edu

More articles from Life Sciences:

nachricht The dense vessel network regulates formation of thrombocytes in the bone marrow
25.07.2017 | Rudolf-Virchow-Zentrum für Experimentelle Biomedizin der Universität Würzburg

nachricht Fungi that evolved to eat wood offer new biomass conversion tool
25.07.2017 | University of Massachusetts at Amherst

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA mission surfs through waves in space to understand space weather

25.07.2017 | Physics and Astronomy

Strength of tectonic plates may explain shape of the Tibetan Plateau, study finds

25.07.2017 | Earth Sciences

The dense vessel network regulates formation of thrombocytes in the bone marrow

25.07.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>