Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stat5 protein inhibits spread of breast cancer cells

04.02.2005


The presence of a protein known as Stat5 prevents laboratory-grown breast cancer cells from becoming invasive and aggressive, according to new research from Georgetown University. The research, which appears in the January 27 issue of Oncogene, could one day lead to advanced therapies for breast cancer patients.



"This new insight is significant because it is the invasive behavior of breast cancer cells that leads to the formation of metastatic cancer, the most advanced and serious form of the disease," said Hallgeir Rui, MD, PhD, associate professor of oncology, Lombardi Comprehensive Cancer Center at Georgetown University and principal investigator of the study.

The research, which was funded by the National Institutes of Health and the Department of Defense, showed that when Stat5 was active, breast cancer cells were not only less invasive, but also aggregated into clusters, resembling healthy breast cells. Conversely, loss of Stat5 stimulated invasive tumor cell activities.


"The apparent suppressive role of Stat5 in breast cancer is surprising in light of the tumor promoting role that Stat5 appears to play in leukemias, lymphomas, and prostate cancer," said Rui. "On the other hand, the new data may not be so unexpected since Stat5 is known to promote differentiation of healthy breast cells. Differentiation is a form of orderliness that is gradually lost as cancer cells become more aggressive and invasive."

Stat5 is a DNA-binding protein that regulates expression of certain genes, many of which remain unknown. During pregnancy, Stat5 is activated by the hormone prolactin, and stimulates milk production in the breast. In related research, Rui and colleagues have recently shown that Stat5 remains active in healthy breast cells in non-pregnant women. However, active Stat5 is lost in many breast cancers, especially as the tumors become more aggressive and metastatic.

Rui cautions that this research was done with cancer cells cultured in the laboratory and that additional studies are needed to determine whether Stat5 also inhibits invasion of human breast cancer cells tested in mice. These studies are underway and the outcome will determine whether new therapies could be designed to one day take advantage of the invasion-suppressive role of Stat5 in breast cancer. Because Stat5 is a protein that is located inside the cell, it cannot be administered in the form of injections to slow down breast tumor cells. However, Rui’s laboratory is exploring alternative ways of switching Stat5 back on in breast cancer.

The results of this study support related research done last year by Rui and his colleagues: In a study that was published in the June 1, 2004 issue of the Journal of Clinical Oncology, the team identified Stat5 as a biomarker of a type of breast cancer that is associated with a favorable prognosis in patients. In fact, in breast cancer patients whose tumors had not yet spread to the nearby lymph nodes, loss of Stat5 was associated with a nearly 7.5-fold increased risk of death from recurring breast cancer. The new research now provides a mechanism to explain why Stat5 may be a useful tumor marker to predict risk and outcome in early stage breast cancer patients.

Amy DeMaria | EurekAlert!
Further information:
http://www.georgetown.edu

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>