Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cell research signals cancer hope

04.02.2005


Scientists have moved a step closer to understanding what happens when cells receive a faulty signal that is known to be a cause of cancer.



Many different types of signal control normal cell development but when some of these signals are ‘mis-activated’ they can result in the formation of tumours. Now, a team of researchers at The University of Manchester has discovered that the way cells communicate with each other is often more complicated than previously thought.

The breakthrough should help in the fight against cancer as understanding how these signals work in healthy cells means scientists can better investigate what happens when the signal goes wrong. Dr Martin Baron, who led the research, said the discovery could take scientists down a new route in their battle against the disease.


Dr Baron’s research, published in the science journal Current Biology, has been concerned with signals that are picked up by a receptor on the surface of the cell known as ‘Notch’, which has been linked to a form of leukaemia called T-ALL.

The Notch receptor, of which there are four types in humans, is unusual in that once it has picked up a signal, it splits into two and part of it actually becomes the signal on its journey to the cell nucleus. What Dr Baron has discovered is that the journey taken by the Notch signal to the nucleus is not as straightforward as scientists first believed. “Our studies have shown how the signal should work normally and how it can be mis-activated,” explained Dr Baron. “If the signal is mis-activated it can cause cancer, so it is important that we know why it can go wrong and find out how to stop it.

“Once we know the process of how the wrong signal is sent and the cell is mis-activated, we can look at the possibility of manipulating the signal or switching it off completely.”

Aeron Haworth | alfa
Further information:
http://www.manchester.ac.uk

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>