An enzyme that initiates inflammation has been directly linked to insulin resistance and resulting type II diabetes by researchers at the University of California, San Diego (UCSD) School of Medicine. In addition, the team suggests that inhibition of the enzyme in the immune systems macrophages may be a new diabetes therapy.
Published in the February 2005 issue of the journal Nature Medicine, the study describes research in mice that identifies enzyme IkB kinase â (Ikk-â) as a central coordinator of inflammatory responses in the liver and macrophages, the immune system cells which attack infections.
Both control mice and mice with Ikk-â deleted in specific types of cells were fed a high-fat diet that normally causes metabolic syndrome and type II diabetes. While the control mice developed the diabetes and insulin-resistant symptoms, mice in which the Ikk-â was deleted from microphages retained their healthy insulin levels.
Sue Pondrom | EurekAlert!
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