Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

T cells target HIV in a relationship on the rebound

21.01.2005


After a break in antiretroviral drug therapy in HIV-positive patients, the virus rebounds and begins to multiply. While this was feared to destroy, perhaps irreversibly, patient HIV-specific CD4+ T cells that are preferentially infected by the virus, it has now be shown to actually boost HIV-specific T cell production and activation, thereby boosting the immune response to the virus.



Scheduled interruption and resumption of antiretroviral treatment of HIV-positive patients has generated hopes of reducing drug toxicities, costs, and total treatment time. However there has been concern regarding how this on and off cycling of drug therapy effects viral replication and the patient’s ongoing immune response to viral infection. While it was implied that even at high viral loads a small population of these HIV-specific CD4+ T cells remained, they have been difficult to quantify.

Rodney Phillips and colleagues from the University of Oxford developed a highly sensitive technique to visualize, quantify, and track the HIV-specific CD4+ T cell population in patients with early-stage HIV infection who were given a short, fixed course of antiretroviral therapy. They found that return of viral replication after cessation of treatment does not destroy this important T cell population – their numbers were in fact comparable to the numbers observed during therapy. Furthermore, the turnover of these virus-specific cells was increased and the CD4+ T cells were prompted to mature into what are known as effector cells, capable of exerting an immune function that helps coordinate other cells of the immune system to eliminate the virus.


The study will appear online on January 20 in advance of print publication in the February 1 edition of the Journal of Clinical Investigation.

Brooke Grindlinger | EurekAlert!
Further information:
http://www.the-jci.org

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>