Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genes in the interferon system important in SLE

19.01.2005


Two genes with very strong associations with the disease SLE have been identified by a team of scientists headed by researchers at the Department of Medical Sciences at Uppsala University. The findings are being published today on the Web page of the highly prestigious American Journal of Human Genetics.



“These findings are probably the first genetic pieces of a huge ‘interferon puzzle,’ with whose help it will be possible to discover the mechanisms behind the disease SLE, and maybe other autoimmune diseases at the molecular level,” says Professor Lars Rönnblom.

“It is remarkable that by studying only eleven of the some 200 genes that are seen as belonging to the interferon system, we were able to identify two genes with such clear connection to SLE,” says Professor Ann-Christine Syvänen.


A few years ago Lars Rönnblom and Professor Gunnar Alm at the Swedish University of Agricultural Sciences were virtually the only researchers who claimed that the interferon system, which is involved in the body’s defense against viruses, etc., was also behind the autoimmune disease SLE. Since then they have shown the importance of the interferon system in a number of works. This has led to the recognition of their hypothesis in the last year, and today it represents a white-hot field of research that has attracted a great deal of interest in the pharmaceutical industry. This picture has now been further reinforced by new findings­ - the result of multidisciplinary and international collaboration involving world experts on the interferon system, immunology, and the disease SLE, combined with world leaders in the technology for large-scale genetic analyses and statistics. The genetic and statistical analyses were performed by the doctoral student Snaevar Sigurdsson and Professor Ann-Christine Syvänen at the Center for Clinical Medical Research at Uppsala University.

The study, comprising nearly 2,000 individuals, shows that two genes in the interferon system are very strongly associated with the disease SLE. One of the genes codes for a so-called thyrosinkinase enzyme, whose function is to convey signals from interferon outside the cells to the cell nucleus.

“We found that genetic variants of thyrosinkase protect against SLE. It probably has an inhibited function that blocks the interferon effect. It is therefore possible to imagine the development of methods of treatment for SLE based on blocking the function of the thyrosinkinase enzyme,” explains Lars Rönnblom.

The other gene codes for a transcription factor, which also plays an important role in regulating the interferon effect. Further functional analyses will be necessary to map the molecular mechanisms in detail.

Besides the Rheumatology Clinic at Uppsala Akademiska Hospital, hospitals in Umeå and Lund, in Sweden, and several hospitals in Finland as well as one hospital in Reykjavik provided the project with DNA samples and diagnostic information from SLE patients.

Anneli Waara | alfa
Further information:
http://www.uu.se
http://www.journals.uchicago.edu/AJHG/journal/issues/v76n3/41895/brief/41895.abstract.html

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>