Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New family of genes could serve as a potential cancer marker

11.01.2005


A new family of genes called Novel Structure Proteins (NSP) discovered by researchers in the Sbarro Institute for Cancer Research and Molecular Medicine in Temple University’s College of Science and Technology could have the potential for predicting the possibility of tumor growth in a patient.



The study was done by Nianli Sang, Ph.D., then a doctoral student at the University and now an assistant professor at Thomas Jefferson University and the Cardeza Foundation. It was initiated and led by Antonio Giordano, M.D., Ph.D., director of the Sbarro Institute and co-director of the Center for Biotechnology at Temple. Their findings, "A gene highly expressed in tumor cells encodes novel structure proteins," are reported in the latest issue of Oncogene (Vol. 23, No. 58).

"We succeeded in cloning several related but distinct cDNA that encode for novel structure proteins," says Giordano. "The identification of these clones shows that these genes are unique and that the major structure of these genes encodes for a region of our chromosome that is important to its structural maintenance. Therefore, this gene could be very important in controlling the backbone of our cells."


Giordano says that their initial analysis shows that this family of genes sits mostly in the nucleus of our cells and exhibits the characteristics of a tumor-promoting gene. One form of the gene, NSP5a3a, is highly expressed in some tumor cell lines and could be very useful as a tumor marker, he adds.

"Knowing the genetic status of this family of genes and understanding how the alteration of NSP can affect that genetic status could be a strong indicator of malignancy," explains Giordano. "By analyzing this gene, we may be able to predict the possibility of tumor growth."

Giordano, who discovered the tumor-suppressing gene Rb2/p130 and others such as Cdk9 and Cdk10, says his Temple institute plans further study on the protein that is encoded by the gene. Next steps could include generating tools that would allow researchers to develop a more precise diagnostic test into whether the cells containing NSP are potentially tumorigenic.

He adds that the in the future this gene may also be used as a specific target for cancer therapies. Drugs could be developed that would inhibit the genes’ tumor-promoting activity, he says.

"The discovery of NSP adds another important player to the race for understanding the molecular mechanisms behind the transformation for normal cells into cancer cells," says Giordano. "This family of genes is going to add another critical tool in trying to understand the errors of genetic language and the progression of cancer, therefore giving researchers possible new solutions to reversing this dreadful disease."

Preston M. Moretz | EurekAlert!
Further information:
http://www.temple.edu
http://www.shro.org

More articles from Life Sciences:

nachricht Fingerprint' technique spots frog populations at risk from pollution
27.03.2017 | Lancaster University

nachricht Parallel computation provides deeper insight into brain function
27.03.2017 | Okinawa Institute of Science and Technology (OIST) Graduate University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Northern oceans pumped CO2 into the atmosphere

27.03.2017 | Earth Sciences

Fingerprint' technique spots frog populations at risk from pollution

27.03.2017 | Life Sciences

Big data approach to predict protein structure

27.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>