Researchers knew that prions, the misfolded proteins that cause mad cow disease and other brain disorders, were killing off a class of important brain cells in a transgenic mouse model. But when they found a way to rescue those cells, they were astonished to discover the mice still became sick.
Now they believe previous efforts to find the beginnings of the mouse disorder may have been focused on the wrong part of the brain cell and are plotting new directions for research.
In a study that appears in the Jan. 1 issue of the Proceedings of the National Academy of Sciences, scientists report evidence that clinical symptoms in the mice are produced by damage to synapses, the areas where nerve cell branches come together for communication. "This could have important therapeutic implications," says senior author David Harris, M.D, Ph.D, professor of cell biology and physiology at Washington University School of Medicine in St. Louis. "There’s a great deal of effort being put into developing treatments for neurodegenerative disorders that would inhibit neuron death. Our results suggest that if we just prevent cell death without doing something to maintain the functionality of the synapse, patients may still get sick."
Michael C. Purdy | EurekAlert!
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The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
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