A Swedish case where a certain type of stem cells has been transplanted to a foetus with a serious disease, was made public today. The results suggest that fetal mesenchymal stem cells may be a valuable source for transplantation and cell therapies.
A female foetus with multiple intrauterine fractures, diagnosed as severe osteogenesis imperfecta, was transplanted with HLA-mismatched mesenchymal stem cells (MSCs) in the 32nd week of gestation. At 35 weeks, the baby girl was delivered by caesarean section. At nine months of age patient lymphocyte proliferation against donor MSCs was not observed in co-culture, indicating that the patient was not immunised against the allogeneic cells.
During the first two years of life three fractures were noted and growth followed the same curve. Thus, allogeneic mis-matched MSCs can be safely transplanted in utero to a patient with severe OI, where the cells engraft in bone. MSCs are present in various tissues of fetal and adult origin. Fetal MSCs differentiated into osteogenic, chondrogenic and adipogenic lineages when induced in vitro, which means that they have the capability to mature into bone, cartilage and fat tissue.
Ulla Bredberg-Rådén | alfa
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A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
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