Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fewer calories may slow Alzheimer’s

16.12.2004


A restrictive diet in mice reduces the build-up of a substance linked to memory loss. But can the findngs be applied to humans?



Restricting the diets of mice reduces the build-up of plaques in the brain that are linked to Alzheimer’s disease, according to a USC study. With obese people generally considered to be at a higher risk for developing Alzheimer’s, the research raises questions about whether the findings are potentially applicable to humans. "This is the first indication that modest changes in the normal diet can slow some aspects of Alzheimer’s disease," said Caleb Finch, co-author of the study published in the online version of the journal Neurobiology of Aging. "But that is far and away yet to be proven for humans. It’s a big jump to say that what’s true for a mouse in a cage is relevant to people living in our complex world," Finch said.

In the study, conducted with collaborators at the University of South Florida in Tampa, researchers used mice whose DNA had been altered with human genes from two families with early onset hereditary Alzheimer’s. The mice were then split into two groups as young adults: one that could eat all it desired ("ad libitum") and the other that had its food intake reduced by 40 percent over a four-week period (diet- restricted).


The researchers were looking specifically at the formation of plaques caused by a build-up of the fiber-like substance called beta-amyloid. Made up of proteins and polysaccharides, amyloid plaques are deposited in the brain during Alzheimer’s disease. Specifically, plaques accumulate in the hippocampus and frontal cortex of Alzheimer’s sufferers - areas responsible for memory.

In the diet-restricted mice, both the amount and size of plaque was about 50 percent less than in mice that ate as much as they wanted. "The power of this study is that two different sets of [human] family mutations were equally sensitive to the effect of diet and slowing the Alzheimer’s-like change," said Finch, holder of the ARCO-William F. Kieschnick Chair in the Neurobiology of Aging at USC.

The next goal is to find out why diet restriction has such profound and rapid effects, Finch said. "We are going to look into the details of metabolism to try and isolate which of the consequences of diet restriction is at work," Finch said. "Is it the blood glucose? Is it the lowered insulin? Those are two targets."

The other USC researchers on this study were Nilay V. Patel, a former USC postdoc who is now a staff scientist at City of Hope Medical Center, and Todd E. Morgan, a research assistant professor in the Andrus Gerontology Center at USC.

The researchers at the University of Southern Florida are Marcia Gordon, Karen E. Connor, Robert A. Good, Robert W. Engelman, Jerimiah Mason and David G. Morgan.

Usha Sutliff | EurekAlert!
Further information:
http://www.usc.edu

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>