Scientists have uncovered a link between a family of genes and abnormalities of the immune system that are associated with systemic lupus erythematosus (SLE), a devastating disease that affects over 1 million Americans. The research, published in the December issue of Immunity, significantly advances the understanding of the pathology of lupus-like autoimmunity in mice and may facilitate the design of future therapies for lupus in humans.
A normal immune system protects the body against viruses, bacteria and other potentially harmful foreign invaders. In an autoimmune disease, like SLE, the immune system loses its ability to tell the difference between foreign substances that pose a threat and the cells of the body. In SLE, the immune system attacks and damages the bodys own tissues and organs, including the joints, kidneys, heart, lungs, brain, blood and skin. Dr. Edward K. Wakeland from the University of Texas Southwestern Medical Center and colleagues used a lupus-prone mouse model of SLE to characterize genes directly involved with SLE susceptibility.
The researchers report that variations in the structure and expression of a subset of genes belonging to the SLAM/CD2 family may contribute to autoimmunity in mice with lupus. Scientists have known for some time that SLAM/CD2 genes play a critical role in controlling immune cells and responses. Evidence presented here suggests that the altered SLAM/CD2 members may be responsible for abnormal lymphocyte responses. The Ly108 gene, which is expressed at elevated levels in lymphocytes from lupus susceptible mice, has emerged as a likely contributor to abnormal immune activation. However, Ly108 and other SLAM/CD2 genes are thought to act in combination with additional genes and signaling molecules in these mice and further research is needed to identify the specific interactions that lead to an overzealous immune response.
Heidi Hardman | EurekAlert!
Decoding the genome's cryptic language
27.02.2017 | University of California - San Diego
New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
27.02.2017 | Materials Sciences
27.02.2017 | Interdisciplinary Research
27.02.2017 | Life Sciences