Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cigarette Smoke A Culprit in Poor Healing and Increased Scarring

07.12.2004


UC Riverside Research Showing How Smoke Complicates Healing Process Selected by Cell Biology Society as Press-Worthy from More Than 1,200 Submissions



Cigarette smoke, whether first- or second-hand, complicates the careful cellular choreography of wound healing, according to a paper by University of California, Riverside researchers that was included in the 2004 Press Book of the 44th Annual Meeting of the American Society For Cell Biology (ASCB).

Cigarette smoke delays the formation of healing tissue and sets the stage for increased scarring at the edges of a wound according to the paper titled Smoke Gets In Your Wounds, one of 15 from a field of more than 1,200 submissions to the ASCB Annual Meeting Press Book.


UCR Professor of Cell Biology and Neuroscience Manuela Martins-Green will present her findings Sunday, Dec. 5, at the annual meeting, which is scheduled to begin Saturday, Dec. 4, in Washington D.C. and will run through Wednesday, Dec. 8.

The press book is the ASCB’s major effort to open cell biology research to a wider audience by helping science journalists discover the meeting’s most exciting and significant new work, according to an association statement.

Martins-Green, and student Lina Wong are part of a team of researchers who have published several papers on the subject. Similar findings were announced in the journals BMC Cell Biology in April and Wound Repair and Regeneration in August. Those papers also examined the role of fibroblasts, the cells that play a major role in wound healing.

Wound healing is a highly choreographed, biological drama of clotting, inflammation, cell proliferation and tissue remodeling. It features an exotic cast of clotting and growth factors, specialized cells and structural proteins, each of which must time their entrance and exit perfectly. Nothing messes up this timing like cigarette smoke. Clinical studies have consistently shown that individuals exposed to cigarette smoke – whether “first-” or “second-hand”– heal poorly and are more likely to develop scarring and associated diseases.

The negative effects of smoking on cells during the inflammatory phase of tissue repair are well documented. However the effects of cigarette smoke on the phase in which fibroblasts proliferate and migrate to create healing tissue, are less understood.

Using doses of cigarette smoke equivalent to “first-hand” and “second-hand” exposure in humans, Martins-Green and her colleagues focused on the structure and function of fibroblasts, both in mice and in human tissue culture.

Fibroblasts secrete many proteins that compose a matrix of connective tissue outside of the cells and are critical in orchestrating tissue repair and remodeling. Surprisingly, smoke, at levels found in tissues of smokers, did not kill the fibroblasts, but instead injured them in a way that allowed them to turn on certain genes that improved their survival. However, it was cell survival at the wrong time and in the wrong place, in terms of properly forming healing tissue.

During normal development of wound healing tissue, the fibroblasts at the site of the wound produce proteins that form a matrix into which fibroblasts and endothelial cells (which form linings of, among other things, blood and lymph vessels and the heart) migrate from outside the wounded tissue. These cells then knit the healing tissue together.

While smoke stimulates these cells to stay alive, it impairs their ability to move, causing them to bunch up at the margin of the wound, which promotes scarring. Both the mouse studies and human cell culture models of wound healing gave the same results, according to Martins-Green.

“Taken together, our results suggest that tobacco smoke may delay wound repair because of the inability of the fibroblasts to migrate into the wounded area, leading to an accumulation of these cells at the edge of the wound, thus preventing the formation of the healing tissue,” she said.

Martins-Green added that: “We’re now trying to isolate the component or components in smoke that inhibit cell migration.”

Ricardo Duran | EurekAlert!
Further information:
http://www.ucr.edu

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>