Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cigarette Smoke A Culprit in Poor Healing and Increased Scarring

07.12.2004


UC Riverside Research Showing How Smoke Complicates Healing Process Selected by Cell Biology Society as Press-Worthy from More Than 1,200 Submissions



Cigarette smoke, whether first- or second-hand, complicates the careful cellular choreography of wound healing, according to a paper by University of California, Riverside researchers that was included in the 2004 Press Book of the 44th Annual Meeting of the American Society For Cell Biology (ASCB).

Cigarette smoke delays the formation of healing tissue and sets the stage for increased scarring at the edges of a wound according to the paper titled Smoke Gets In Your Wounds, one of 15 from a field of more than 1,200 submissions to the ASCB Annual Meeting Press Book.


UCR Professor of Cell Biology and Neuroscience Manuela Martins-Green will present her findings Sunday, Dec. 5, at the annual meeting, which is scheduled to begin Saturday, Dec. 4, in Washington D.C. and will run through Wednesday, Dec. 8.

The press book is the ASCB’s major effort to open cell biology research to a wider audience by helping science journalists discover the meeting’s most exciting and significant new work, according to an association statement.

Martins-Green, and student Lina Wong are part of a team of researchers who have published several papers on the subject. Similar findings were announced in the journals BMC Cell Biology in April and Wound Repair and Regeneration in August. Those papers also examined the role of fibroblasts, the cells that play a major role in wound healing.

Wound healing is a highly choreographed, biological drama of clotting, inflammation, cell proliferation and tissue remodeling. It features an exotic cast of clotting and growth factors, specialized cells and structural proteins, each of which must time their entrance and exit perfectly. Nothing messes up this timing like cigarette smoke. Clinical studies have consistently shown that individuals exposed to cigarette smoke – whether “first-” or “second-hand”– heal poorly and are more likely to develop scarring and associated diseases.

The negative effects of smoking on cells during the inflammatory phase of tissue repair are well documented. However the effects of cigarette smoke on the phase in which fibroblasts proliferate and migrate to create healing tissue, are less understood.

Using doses of cigarette smoke equivalent to “first-hand” and “second-hand” exposure in humans, Martins-Green and her colleagues focused on the structure and function of fibroblasts, both in mice and in human tissue culture.

Fibroblasts secrete many proteins that compose a matrix of connective tissue outside of the cells and are critical in orchestrating tissue repair and remodeling. Surprisingly, smoke, at levels found in tissues of smokers, did not kill the fibroblasts, but instead injured them in a way that allowed them to turn on certain genes that improved their survival. However, it was cell survival at the wrong time and in the wrong place, in terms of properly forming healing tissue.

During normal development of wound healing tissue, the fibroblasts at the site of the wound produce proteins that form a matrix into which fibroblasts and endothelial cells (which form linings of, among other things, blood and lymph vessels and the heart) migrate from outside the wounded tissue. These cells then knit the healing tissue together.

While smoke stimulates these cells to stay alive, it impairs their ability to move, causing them to bunch up at the margin of the wound, which promotes scarring. Both the mouse studies and human cell culture models of wound healing gave the same results, according to Martins-Green.

“Taken together, our results suggest that tobacco smoke may delay wound repair because of the inability of the fibroblasts to migrate into the wounded area, leading to an accumulation of these cells at the edge of the wound, thus preventing the formation of the healing tissue,” she said.

Martins-Green added that: “We’re now trying to isolate the component or components in smoke that inhibit cell migration.”

Ricardo Duran | EurekAlert!
Further information:
http://www.ucr.edu

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>