Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

’Death clock’ gene hunt success for University of Leicester medical scientists

17.11.2004


Medical scientists at the University of Leicester have announced they have narrowed the search for the ’death clock’ gene in humans. Their study relates to a hunt for a gene that has important implications for aging and cancer as well as other age-related diseases.



The gene controls the length of human telomeres - repeat DNA sequences that cap a chromosome. Each time a human cell divides, the cap shortens. When it gets too short, cells die. Telomere length therefore acts as a ’death clock’
People vary considerably in the length of telomeres they are born with.

The Leicester team, comprising members of the Department of Cardiovascular Sciences, Health Sciences and Genetics linked inter-individual differences in telomere length to a region on Chromosome 12 and identified what they describe as a ’strong candidate’ for the ’death clock’ gene. To help locate the gene, the Leicester researchers examined 383 adults comprising 258 sibling pairs.



The authors state in The American Journal of Human Genetics: "Identification of the gene involved and elucidation of its mechanism of action could have important implications for our understanding of chromosomal assembly, telomere biology, and susceptibility to age-related diseases."

Professor Nilesh Samani, Professor of Cardiology at the University of Leicester, who headed the research team added: "Our interest in this area is linked to our work on coronary heart disease where we have shown that shorter telomere length is associated with coronary atherosclerosis and risk of premature heart attacks. However, telomere biology is relevant to many other conditions, including cancer where telomere length is maintained, and hence finding of a major gene that regulates telomere length and understanding how it works could have wide implications."

In addition to Professor Samani, the research team included Dr Mariuca Vasa-Nicotera, Mr Scott Brouilette, Dr Massimo Mangino, Professor John R Thompson, Mr Peter Braund, Ms Jenny-Rebecca Clemitson, Ms Andrea Mason, Mrs Clare L. Bodycote, Dr Stuart M. Raleigh and Professor Edward Louis.

Ather Mirza | alfa
Further information:
http://www.le.ac.uk

More articles from Life Sciences:

nachricht Decoding the genome's cryptic language
27.02.2017 | University of California - San Diego

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New pop-up strategy inspired by cuts, not folds

27.02.2017 | Materials Sciences

Sandia uses confined nanoparticles to improve hydrogen storage materials performance

27.02.2017 | Interdisciplinary Research

Decoding the genome's cryptic language

27.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>