Scientists at Johns Hopkins and the University of Texas Medical Branch have created a new tool that easily reveals when and where a key cellular signal is active. The development, described in the early edition of the Proceedings of the National Academy of Sciences, should speed identification of the signals triggers and effects in normal processes and in conditions such as asthma, allergy, inflammation, lung disease and heart disease.
The tool -- a special fluorescent protein -- probes the activity of cyclic AMP in living cells and represents biologys growing application of a fluorescent phenomenon to study the molecular changes that reveal cells inner workings. Much like a child might pass along a visitors request to a grown-up, cyclic AMP carries messages from hormones or other molecules "knocking" at the cells door to proteins inside the cell. But because cyclic AMP uses just a handful of proteins to pass on many messages, scientists have had a hard time figuring out how it can trigger the right cellular response to each one.
"Scientists suspected that timing and location of cyclic AMP activity was important, but there was no easy way to study cyclic AMP inside cells in real time and in real space," says Jin Zhang, Ph.D., senior author of the study and an assistant professor of pharmacology and molecular sciences and of neuroscience in Johns Hopkins Institute for Basic Biomedical Sciences. "This new fluorescent protein can be directed to the nucleus or to other parts of the cell, so we can now follow cyclic AMP activity in real time and space."
Joanna Downer | EurekAlert!
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Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
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16.01.2017 | Power and Electrical Engineering
16.01.2017 | Information Technology
16.01.2017 | Power and Electrical Engineering