Drug discovery researchers at Northwestern University have developed a new class of compounds that have the potential to reduce the inflammation of brain cells and the neuron loss associated with Alzheimers disease.
The new class of compounds are aminopyridazines. The original compound, called MW01-070C, is used in an injectable form. More recently developed compounds, such as MW01-2-151WH and MW01-5-188WH, can be taken by mouth.
The compounds were designed and synthesized in the laboratory of D. Martin Watterson, J. G. Searle Professor of Molecular Biology and Biochemistry and professor of molecular pharmacology and biological chemistry, Northwestern University Feinberg School of Medicine, using a synthetic chemistry platform developed by the Northwestern Drug Discovery Program for the rapid discovery of new potential therapeutic targets.
Elizabeth Crown | EurekAlert!
CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften
Toward a 'smart' patch that automatically delivers insulin when needed
18.01.2017 | American Chemical Society
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
19.01.2017 | Studies and Analyses
19.01.2017 | Physics and Astronomy
19.01.2017 | Life Sciences