In studies with mice that develop the equivalent of Alzheimers disease that runs in families, Johns Hopkins researchers have shown that brain cells signals confuse the movement of implanted neuronal stem cells.
The observation reinforces the idea that disease can create "microenvironments" that affect the behavior of cells. These local environments might help recruit stem cell-based therapies in other conditions, say the researchers. The findings are to be presented Oct. 25 at the annual meeting of the Society for Neuroscience by first author Zhiping Liu, Ph.D., a research associate in pathology.
"In normal adult mice, stem cells taken from the olfactory bulb returned to the olfactory bulb -- they returned to where they belong -- even though they had come from a different mouse," says Lee Martin, Ph.D., associate professor of pathology and neuroscience at Hopkins. "In mice with Alzheimers disease, the stem cells went all over the place within the brain, responding to a multitude of signals whose identities we dont even know."
Joanna Downer | EurekAlert!
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