Study Helps Explain Why Albuterol Benefits Some Asthma Patients More Than Others
Genes affect how asthma patients respond to albuterol, according to results of a new study of adults with mild asthma. Researchers in the Asthma Clinical Research Network (ACRN) of the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, found that over time, how participants responded to daily doses of inhaled albuterol differed depending on which form of a specific gene they had inherited. While a few weeks of regular use of albuterol improved overall asthma control in individuals with one form of the gene, stopping all use of albuterol eventually improved asthma control in those with another form of the gene. Albuterol is the most commonly used drug for relief of acute asthma symptoms, or “attacks.”
The Beta-Adrenergic Response by Genotype (BARGE) trial is the first study of an asthma drug in patients selected according to their genotype, or which forms of a specific gene they have. Published in the October 23-29 issue of the Lancet,* the BARGE trial provides important insight as to why albuterol may benefit some people with asthma more than others. The findings could lead to better ways to individualize asthma therapy based on patients’ genetic patterns. “If we can pinpoint which individuals will do better with a certain type of therapy, we can improve their lives more quickly and save them -- and the healthcare system -- the expense and risk of trying drugs that are less effective for them,” comments Dr. Barbara Alving, NHLBI acting director. “This study helps put asthma at the forefront of pharmacogenetics.”
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy