Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bloodroot alkaloid aids in exterminating sun-damaged skin cells in culture

20.10.2004


A common antibacterial and antifungal ingredient used in mouthwashes and tooth paste may have another positive medicinal use: protection against skin cancer.

According to new studies, sanguinarine was shown to enhance production of proteins that induce cell death, or apoptosis, in cells damaged by ultraviolet-B (UVB) radiation. The alkaloid also restricts skin cell production of other pro-proliferation proteins. "This natural compound may protect skin from cells that acquire the genetic damage caused by UV radiation from advancing toward cancer," said Nihal Ahmad, assistant professor, Department of Dermatology, the University of Wisconsin, Madison. "It is conceivable that sanguinarine may be used as a chemopreventive agent against skin cancer when used topically, supplemented with a sun screen."

Ahmad studies with sanguinarine were presented at the Third Annual American Association for Cancer Research International Conference on Frontiers in Cancer Prevention Research held here from October 16-20. Sanguinarine is an alkaloid present in the bloodroot plant, and is considered to have anti-bacterial, antifungal and anti-inflammatory properties. Sanguinarine is used widely in toothpastes and mouthwashes for the prevention of inflammatory conditions such as gingivitis.



Skin cell that were pretreated with sanguinarine and then exposed to UVB increased synthesis of the Bax protein and decreased production of Bcl-2, shifting cellular balance toward engineering apoptosis of the skin cells. Sanguinarine amplified the normal apoptotic response of skin cells exposed to UVB. UVB induced a 31-46 percent decrease in cell viability, and a 49-66 percent increase in the number of cells entering apoptosis. By pre-treating the cells with a low concentration (50 nM) of sanguinarine, Ahmad and his associates observed that the natural plant-based anti-oxidant agent induced a 54-72 percent decrease in cell viability after UVB. The rate of apoptosis increased an additional 49-66 percent after sanguinarine treatment prior to UVB irradiation.

By itself, sanguinarine had no effect on skin cell viability, apoptosis, or cell cycle distribution.

Warren Froelich | EurekAlert!
Further information:
http://www.aacr.org

More articles from Life Sciences:

nachricht New photocatalyst speeds up the conversion of carbon dioxide into chemical resources
29.05.2017 | DGIST (Daegu Gyeongbuk Institute of Science and Technology)

nachricht Copper hydroxide nanoparticles provide protection against toxic oxygen radicals in cigarette smoke
29.05.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Strathclyde-led research develops world's highest gain high-power laser amplifier

The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.

The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

New insights into the ancestors of all complex life

29.05.2017 | Earth Sciences

New photocatalyst speeds up the conversion of carbon dioxide into chemical resources

29.05.2017 | Life Sciences

NASA's SDO sees partial eclipse in space

29.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>