Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UNC scientists identify sticky protein in sickle cell red blood cells

13.10.2004


New research from the University of North Carolina at Chapel Hill reveals why red blood cells from people with sickle cell disease are stickier than healthy red cells, pointing the way to potential new treatments for sickle cell disease. The study shows that a protein found on the surface of immature red blood cells, or reticulocytes, is responsible for those cells’ adhesion to blood vessel walls.



Reticulocytes are found at considerably higher levels in the blood of sickle cell patients than healthy patients, and so the likelihood of sticky patches or blockages forming on a blood vessel wall is greatly increased. The blockages lead to problems including strokes, pneumonia, recurring infections and painful episodes known as crises that often require hospitalization. The new findings appear in the Oct. 8 issue of the Journal of Biological Chemistry.

The work of Dr. Julia Brittain provides new clues to better controlling stickiness of sickle red blood cells, said Dr. Leslie Parise, professor and vice chair of pharmacology at UNC’s School of Medicine. Brittain is a postdoctoral fellow in Parise’s laboratory. "It was previously thought that sickle red blood cells lodged in blood vessels because they’re sickle-shaped, more rigid and just became physically stuck," said Brittain, the study’s co-author. "But while the physical lodging is a component, an equally important component is that sickle red blood cells are simply stickier."


Brittain and her co-authors showed that the cell-surface protein Alpha-4Beta-1 is activated by another cell-surface protein, CD47, and that Alpha-4Beta-1 was responsible for sickle red blood cell adhesion to a blood vessel wall protein called thrombospondin.

CD47 binds to and is activated by soluble, blood-borne thrombospondin, which is found elevated in sickle cell patients and which initiates an atypical signaling cascade inside the red blood cells. This aberrant signaling ultimately culminates in the activation of Alpha-4Beta-1 and an increase in red blood cells sticking to the blood vessel wall, said Brittain.

"Even though sickle cell patients are particularly vulnerable to blocked blood vessels, the signaling mechanisms identified in sickle reticulocytes seem to be present in reticulocytes found in other anemic patients as well," said Brittain. "Our current thinking is that these results may benefit patients suffering from a number of anemias and not just sickle cell disease" The UNC study also identified where Alpha-4Beta-1 binds to thrombospondin. "This knowledge opens the door to possible therapies. Inhibitors of the class of proteins to which Alpha-4Beta-1 belongs, the integrins, are being tested for use in diseases such as Crohn’s disease, and these inhibitors are now attractive and rational therapies for sickle cell disease," said Parise.

L.H. Lang | EurekAlert!
Further information:
http://www.med.unc.edu

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>