Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene expression in liver tumors and patient prognosis

14.09.2004


Liver cancer genes cluster into two subsets that correlate to survival



An analysis of the gene expression patterns of 91 unrelated liver tumors revealed two distinctive subclasses highly associated with patient survival, according to a new study published in the September 2004 issue of Hepatology.
Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD), published by John Wiley & Sons, Inc., is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/hepatology.

The study is among the first to explore the complete molecular pathogenesis of hepatocellular carcinoma (HCC). It identified expression profiles of a limited number of genes that accurately predicted length of patient survival and these findings may open the door to the development of more targeted therapies for liver cancer patients.



While gene technology has previously been applied to some specific aspects of liver cancer, researchers led by Dr. Snorri Thorgeirsson of the NIH’s National Cancer Institute, sought to uncover molecular prognostic indices that could be applied to the overall patient population with HCC. They investigated variations in gene expression in HCC at diagnosis and compared them to patient survival over time.

The researchers examined 91 HCC tissues, 60 matched non-tumor surrounding liver tissues, and 18 normal liver samples. They isolated total RNA to derive complementary DNA and characterized each sample’s gene expression profile. They applied three independent approaches for data analysis to uncover subclasses of HCC and the underlying biological differences between the subclasses.

The study yielded two distinct subclasses of HCC that were highly associated with patient survival and provided new molecular insight into the pathogenesis of HCC. Tumors from the low survival subclass had a strong cell proliferation and antiapoptosis gene expression signatures. They also had higher expression of genes involved in ubiquitination and histone modification, which suggests an involvement of these processes in aggressive HCC.

"Our results indicate that HCC prognosis can be readily predicted from the gene expression profiles of primary tumors," the authors report. Furthermore, they suggest that the unique molecular characteristics of each subclass could be useful in developing new therapies for liver cancer patients.

"Even if a curative therapy for HCC patients cannot be offered at this stage, it may be possible to identify therapeutic targets that can slow the course of disease progression," the authors conclude. "For example, small molecules that inhibit activities of some transcription factors are already available and may provide opportunities to alter the course of HCC progression in both subclass A and B."

An accompanying editorial by Joseph Locker, M.D. of Albert Einstein College of Medicine in New York, underscores the conclusions of the study by Lee et al. and points out that their work has produced an extremely large data set that is a valuable resource for many kinds of studies.

"Lee et al. focused on unsupervised clustering and prognosis, but there are numerous other important questions that could be approached with further analysis of their comprehensive data sets," writes Locker. "Most important, expression profiling will reveal specific targets for rational therapy."

David Greenberg | EurekAlert!
Further information:
http://www.wiley.com
http://www.interscience.wiley.com/journal/hepatology

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>