A mini-antibody bearing a payload of tumor-busting radiation thwarts the growth of human breast cancer in laboratory animals, according to research published in the September 1 issue of the journal Cancer Research.
The research shows that a diabody, an antibody surrogate just one third the size of native antibodies, can be used effectively as a targeting vehicle for radioimmunotherapy, said Gregory Adams, Ph.D., associate member of the Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pa.
Diabodies are genetically engineered dimeric proteins produced in E. coli bacteria that contain the antigen-recognizing portion of antibodies formed by immune system cells to combat disease. The mini-antibody developed by Adams and colleagues, C6.5K-A, is a protein substitute for larger, naturally produced antibodies that specifically target the HER2/neu human tumor-associated antigen. When loaded with the beta-emitting radioisotope yttrium-90, C6.5K-A significantly inhibits the growth rate of human breast tumor xenografts in mice. "The diabodies bound to the HER2 receptor produced by certain breast tumor cells." said Adams, the lead author on the paper. "Imaging indicated that the diabody was concentrated in the mammary tumors and in the kidney where it was excreted from the body."
Russell Vanderboom, PhD | EurekAlert!
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Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
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In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
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By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
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COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
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