Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New gene identified in breast cancer

30.08.2004


Canadian researchers identify new player in breast cancer

Canadian researchers at the Research Institute of the McGill University Health Centre (Montreal, QC) and McMaster University (Hamilton, ON) have identified a new player in breast cancer. This gene, beta1-integrin, has been shown to be critical in the initiation of tumour growth and development in a mouse model of cancer.

"We are the first to demonstrate the requirement for beta1-integrin in the induction breast cancer in genetically engineered mice, " says senior author Dr. William Muller, a MUHC researcher and professor of Medicine and Biochemistry at McGill University. "Our findings show that blocking the function of this gene halts tumour proliferation. We also show that in our model of breast cancer, tumour cells do not grow without beta1-intergrin. These results demonstrate the importance of this gene in tumour biology. The next step is to look for therapeutics which block this gene in humans."



Dr. Muller and his colleagues from the Department of Biochemistry and Biomedical Sciences at McMaster University, Dr. John Hassel, Natasza Kurpios and Don White, used breast-cancer prone mice to demonstrate the role of beta1-integrin. They initially showed that removing this gene did not effect the normal mammary development of the mice. They then went on to show that if this gene was removed from already growing tumours, the tumours would cease to grow.

"This is an exciting time in breast cancer research," says McMaster University and McGill University graduate student and first author of the study, Don White. "The more players we identify, the more likely we are to cure this disease."

Christine Zeindler | EurekAlert!
Further information:
http://www.muhc.ca
http://www.cancercell.org/ .

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>