An artists depiction shows an atomic force microscope probe (not to scale) fishing for molecular sites recognized by an antibody tethered to the probe by a fine polymer thread. The new technique promises to vastly improve the capabilities of atomic force microscopy.
A team of researchers have developed a method that could vastly improve the ability of atomic force microscopes to "see" the chemical composition of a sample, follow variations of the sample, as well as map its topographic structure.
The advance could have significant implications for drug development by allowing scientists to monitor the effects of potential drugs on an ever-smaller scale, according to Stuart Lindsay, director of the Center for Single Molecule Biophysics at the Biodesign Institute at Arizona State University and a lead researcher on the project.
Lindsay, an ASU professor in the department of physics and astronomy said the new technique allows an atomic force microscope to "see," on a nanometer scale, the chemical composition of molecules.
Skip Derra | EurekAlert!
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Munich Physicists have developed a novel electron microscope that can visualize electromagnetic fields oscillating at frequencies of billions of cycles per second.
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Scientists at the Helmholtz Zentrum München have developed a new mass spectrometry imaging method which, for the first time, makes it possible to analyze hundreds of metabolites in fixed tissue samples. Their findings, published in the journal Nature Protocols, explain the new access to metabolic information, which will offer previously unexploited potential for tissue-based research and molecular diagnostics.
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Chemists at the University of Basel have succeeded in using computer simulations to elucidate transient structures in proteins. In the journal Angewandte Chemie, the researchers set out how computer simulations of details at the atomic level can be used to understand proteins’ modes of action.
Using computational chemistry, it is possible to characterize the motion of individual atoms of a molecule. Today, the latest simulation techniques allow...
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