Anyone who’s endured their share of childhood scrapes has probably heard some version of the motherly admonishment, "Don’t pick that scab, you’ll just make it worse!" It turns out, Mom was on to something, according to research published on-line in the open-access journal PLoS Biology.
Tissue damage in humans triggers a well-characterized response marked by rapid blood clotting and a recruitment of epidermal cells to the injury. When you remove a scab, you’re also removing some of the newly regenerated tissues growing underneath, thereby interfering with the healing process. Many different cell types and proteins have been linked to the repair process, but the complexity of the mammalian wound response has challenged efforts to determine their individual roles.
Michael Galko and Mark Krasnow of Stanford University turned to the quintessential genetics organism, Drosophila melanogaster, to create a novel system for studying wound healing. After stabbing fruitfly larvae with a needle to create a nonfatal puncture wound, the researchers observed the familiar blood clotting and spreading of epidermal cells to promote healing.
22.09.2017 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden
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