A team of researchers from the Universitat Autònoma de Barcelona (UAB) has discovered that transposons, small DNA sequences that travel through the genomes, can silence the genes adjacent to them by inducing a molecule called antisense RNA. This is a new mechanism for evolution that has been unknown until now. The research has been recently published in the journal Proceedings of the National Academy of Sciences (PNAS).
Transposons are repeated DNA sequences that move through the genomes. For a long time they have been considered as a useless part of genetic material, DNA left overs. However, it is more and more clear that transposons can cause favourable changes for the adaptation and survival of the organism.
In this research project, the UAB scientists have demonstrated that a transposon inserted in the genome of the Drosophila (a model used for a lot of genetic studies) silenced a gene adjacent to it, that is, it reduced its level of expression significantly. The expression of a gene consists in using the DNA as a mould to synthesise a molecule called a messenger RNA, which in its own environment will be used to synthesise a particular protein. According to what the researchers have seen, the transposon stimulates the synthesis of a molecule that is complementary to the normal messenger RNA. This new complementary molecule (that the scientists have called antisense RNA) joins with the normal RNA of the gene obstructing it from synthesising the protein. Even though the research has been carried out on the species Drosophila buzzatii, the researchers state that transposons, that in the human genomes represent 45% of the genetic material, could be provoking the same type of silencing effect in our species.
The work now published is a continuation of previous studies. In 1999, the research team headed by Dr. Alfredo Ruiz, from the Department of Genetics and Microbiology at the UAB, published an article in Science where they demonstrated that a chromosomal inversion in Drosophila buzzatii was generated by the transposon activity. The inversions are formed by turning a chromosome segment upside down so that it is orientated in the opposite direction. In Drosophila it has been demonstrated that the chromosomal inversions often have an adaptive value, that is, that the individuals that have chromosomes with the inversion show some advantages over those that don’t, even though it still unclear what is the mechanism used by the inversions to cause these differences.
Octavi López Coronado | alfa
When fat cells change their colour
28.10.2016 | Albert-Ludwigs-Universität Freiburg im Breisgau
Aquaculture: Clear Water Thanks to Cork
28.10.2016 | Technologie Lizenz-Büro (TLB) der Baden-Württembergischen Hochschulen GmbH
Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.
So-called monolayers are at the heart of the research activities. These "super materials" (as the prestigious science magazine "Nature" puts it) have been...
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
28.10.2016 | Power and Electrical Engineering
28.10.2016 | Physics and Astronomy
28.10.2016 | Life Sciences