Current microarray experiments allow the levels of activity of thousands of genes to be measured at once, providing a window into molecular events underlying health and disease. The selection of genes having distinct levels of activity between conditions of interest (such as cancer and non-cancer) has therefore emerged as a key aim of data analysis. However, with typically many thousands of genes to choose from and at most a few dozen sets of measurements available, differential analyses of this kind are extremely challenging. Different statistical tests yield different results due to their underlying assumptions, but on real data it is usually impossible to tell which method is likely to be right.
Researchers at the University of Oxford have developed a new method that is able of provide a consistency measure for such tests. It is capable of assessing the effectiveness of each algorithm for particular data and it can be further utilised to learn how to produce an effective statistical method for testing the given data.
The new method has many distinct advantages and benefits in comparison with existing methods for screening. One of the main advantages is that it is able to assess statistical algorithms by selecting custom algorithms from data using a notion of consistency. The technique, which is extremely robust, helps to reduce the risk of choosing an inappropriate algorithm. This helps to minimise errors and therefore lead to significant potential reduction in the cost of producing data.
What happens in the cell nucleus after fertilization
06.12.2016 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
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