Scientists will have a new view of how the AIDS virus (HIV) enters a target cell and begins its process of infection, thanks to a technique created by researchers at the Salk Institute.
The technique allows scientists to observe for the first time the steps taken by viruses like HIV after they enter a cell. The study was done with a chicken virus that was modified to contain the genes of HIV. Both the chicken virus and HIV are retroviruses, which means their genomes are made from RNA rather than DNA. When the viruses enter a host cell, their RNA genomes are converted to DNA, which integrates into the DNA of the host cell. This step is essential for the formation of new virus particles.
John Young, a Salk professor of infectious disease, and colleague Shakti Narayan reported their findings in the May 18 edition of the Proceedings of the National Academy of Sciences.
Andrew Porterfield | EurekAlert!
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