An international team of researchers from the University of Helsinki, GeneOS Ltd. and partner institutions announced today that it has made significant discoveries on the causes of asthma. The team’s study, published in the April 9, 2004 edition of Science, reports two novel asthma genes and a set of diagnostic single nucleotide polymorphisms (SNPs).
The implications of the finding are that physicians may be able to identify atopic asthma and allergy patients earlier than is currently possible. Even more importantly, the gene that was found to be the risk gene for asthma is well suited for a drug target molecule.
Previous genome-wide scans in multiple populations have suggested that there is a susceptibility region for asthma on chromosome 7p. This study focused its efforts to confirm the hypothesis and to identify the genes in the Finnish families. The results were then replicated among the Canadian families to be sure that the findings are valid also in other populations. A hierarchical genotyping design was used and lead to the identification of a 133kb risk-conferring segment that contained two genes. The data imply that an orphan G-protein receptor named GPRA is involved in the pathogenesis of atopy and asthma and may have application in other inflammatory diseases.
Paivi Lehtinen | alfa
Ambush in a petri dish
24.11.2017 | Friedrich-Schiller-Universität Jena
Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology
High-precision measurement of the g-factor eleven times more precise than before / Results indicate a strong similarity between protons and antiprotons
The magnetic moment of an individual proton is inconceivably small, but can still be quantified. The basis for undertaking this measurement was laid over ten...
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
24.11.2017 | Physics and Astronomy
24.11.2017 | Health and Medicine
24.11.2017 | Earth Sciences