Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Embryonic stem cells induced to develop into bone marrow and blood cells

01.04.2004


Researchers at Northwestern University have devised a method to induce embryonic stem cells to develop into bone marrow and blood cells. Injecting the stem cells into the bone marrow cavity of mice whose bone marrow cells had been depleted restored production of blood cells, including cells of the immune system, which normally are created in the bone marrow.



As reported by Richard K. Burt, M.D., and colleagues in April issue of The Journal of Experimental Medicine, the method was effective even in genetically mismatched mice. If the same results can be produced in humans, the technique may eventually eliminate the need to find genetically matched human bone marrow donors for persons with leukemia, autoimmune diseases and other immune disorders, Burt said.

Burt is associate professor of medicine and chief of immunotherapy for autoimmune diseases at the Feinberg School of Medicine at Northwestern University.


Embryonic stem cells, which are derived from embryos, have the potential to grow into many different cell types. Burt and colleagues identified the most effective mix of growth factors to induce stem cells in culture to develop into precursor bone marrow and blood cells. They also developed a technique to select the most viable cells for injection.

Despite the genetic mismatch between donor and recipient mice, the injected cells were not rejected. The injected cells matured into a new immune system that recognized the recipient as self.

Blood or marrow stem cells from a sibling or an unrelated or cord blood registry often fail to develop tolerance to the recipient or patient into which they are infused – an often-fatal complication after bone marrow transplantation that is known as graft-versus-host disease.

But in the study, after embryonic stem cell transplantation the mice’s immune response, while tolerant to self, responded to foreign substances normally, indicating that recipients are able to fight off infection. Although the use of human embryonic stem cell lines is controversial, it has many advantages over the use of donor bone marrow or blood cells, which are highly variable, cannot be cultured in a laboratory, may cause lethal graft-versus-host disease and are often not available to patients due to inability to find a suitably matched donor.

Human embryonic stem cell lines can be cultured indefinitely, providing a permanently renewable alternative marrow source that restores blood cell production with an intact immune response without causing graft-versus-host disease.

Elizabeth Crown | EurekAlert!
Further information:
http://www.nwu.edu/

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>