An interaction between two brain proteins that leads to abnormal brain development has been identified by researchers at the University of California, San Diego (UCSD) School of Medicine in a study published in the January 22, 2004 issue of the journal Neuron.
The studies in mice, conducted in the lab of Joseph G. Gleeson, M.D., UCSD assistant professor of neurosciences, combines work in both humans and mice to identify a protein kinase called Cdk5 as the “off” switch for a crucial neuronal migration protein called doublecortin. When Cdk5 adds a phosphate molecule to doublecortin, the doublecortin is inactivated and neuronal migration is arrested.
In the normal brain, neurons are born deep within fluid filled cavities of the brain during the third and fourth month of gestation. Then, they must migrate hundreds of cell-body distances to reach their proper position within the six-layered cortex. When this migration is defective and neurons are stopped short of their destination, there is an absence of the normal grooves and ridges that characterize the brain in higher mammals.
Sue Pondrom | UCSD
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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