Researchers have discovered that a specific type of calcium channel -- a pore-like protein that nestles in the cell membrane and controls the flow of calcium into the cell -- regulates the relaxation of coronary arteries.
The studies showed that mice engineered to lack these calcium channels had constricted coronary arteries and had fibrous tissue in their hearts, which was evident when the animals hearts reacted to chronic blood restriction. The researchers hypothesize that drugs targeting this calcium channel might one day be used to treat cardiovascular disease by opening arteries.
The researchers, led by Howard Hughes Medical Institute investigator Kevin Campbell, published their findings in the November 21, 2003, issue of the journal Science. Campbell and his colleagues at the University of Iowa collaborated with researchers from the Veterans Administration Medical Center in Iowa City, Loyola University Medical Center and the University of Texas Southwestern Medical Center.
Jim Keeley | EurekAlert!
Plankton swim against the current
12.12.2017 | Schweizerischer Nationalfonds SNF
To differentiate or not to differentiate?
12.12.2017 | Max-Planck-Institut für Biologie des Alterns
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
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