Pesticides attack same cellular targets as rotenone - already implicated in Parkinsons disease
Scientists at Emory University School of Medicine have found in laboratory experiments that several commonly used pesticides are just as toxic or even more toxic to the mitochondria of cells than the pesticide rotenone, which already has been implicated in the development of Parkinsons disease. The Emory neurologists, led by Tim Greenamyre, MD, PhD and Todd B. Sherer, PhD, will present the results of their comparative research with pesticides at the Society for Neuroscience meeting in New Orleans on Saturday, Nov. 8.
Parkinsons disease, which is one of the most common neurodegenerative diseases, has been associated abnormalities of mitochondria, which are the "power plants" that provide all cells with energy. Rotenone and many other pesticides are known to damage the mitochondria by inhibiting a mitochondrial enzyme called complex I. In earlier experiments, Dr. Greenamyre and his colleagues found that chronic treatment with low levels of rotenone caused gradual degeneration of the dopamine neurons in rats, and reproduced many of the features of Parkinsonism.
In the new study, the Emory scientists exposed human neuroblastoma cells to the pesticides rotenone, pyridaben, fenazaquin, and fenpyroximate, all of which inhibit complex I. Pyridaben was by far the most potent toxic compound, followed by rotenone and fenpyroximate, with fenazaquin being the least toxic. Pyridaben was also more potent than rotenone in producing "free radicals" and oxidative damage to the cells, both of which are thought to be important in causing Parkinsons disease.
Holly Korschun | EurekAlert!
North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich
Researchers Discover New Anti-Cancer Protein
22.03.2018 | Universität Basel
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
22.03.2018 | Trade Fair News
22.03.2018 | Earth Sciences
22.03.2018 | Earth Sciences