Pesticides attack same cellular targets as rotenone - already implicated in Parkinsons disease
Scientists at Emory University School of Medicine have found in laboratory experiments that several commonly used pesticides are just as toxic or even more toxic to the mitochondria of cells than the pesticide rotenone, which already has been implicated in the development of Parkinsons disease. The Emory neurologists, led by Tim Greenamyre, MD, PhD and Todd B. Sherer, PhD, will present the results of their comparative research with pesticides at the Society for Neuroscience meeting in New Orleans on Saturday, Nov. 8.
Parkinsons disease, which is one of the most common neurodegenerative diseases, has been associated abnormalities of mitochondria, which are the "power plants" that provide all cells with energy. Rotenone and many other pesticides are known to damage the mitochondria by inhibiting a mitochondrial enzyme called complex I. In earlier experiments, Dr. Greenamyre and his colleagues found that chronic treatment with low levels of rotenone caused gradual degeneration of the dopamine neurons in rats, and reproduced many of the features of Parkinsonism.
In the new study, the Emory scientists exposed human neuroblastoma cells to the pesticides rotenone, pyridaben, fenazaquin, and fenpyroximate, all of which inhibit complex I. Pyridaben was by far the most potent toxic compound, followed by rotenone and fenpyroximate, with fenazaquin being the least toxic. Pyridaben was also more potent than rotenone in producing "free radicals" and oxidative damage to the cells, both of which are thought to be important in causing Parkinsons disease.
Holly Korschun | EurekAlert!
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