Pesticides attack same cellular targets as rotenone - already implicated in Parkinsons disease
Scientists at Emory University School of Medicine have found in laboratory experiments that several commonly used pesticides are just as toxic or even more toxic to the mitochondria of cells than the pesticide rotenone, which already has been implicated in the development of Parkinsons disease. The Emory neurologists, led by Tim Greenamyre, MD, PhD and Todd B. Sherer, PhD, will present the results of their comparative research with pesticides at the Society for Neuroscience meeting in New Orleans on Saturday, Nov. 8.
Parkinsons disease, which is one of the most common neurodegenerative diseases, has been associated abnormalities of mitochondria, which are the "power plants" that provide all cells with energy. Rotenone and many other pesticides are known to damage the mitochondria by inhibiting a mitochondrial enzyme called complex I. In earlier experiments, Dr. Greenamyre and his colleagues found that chronic treatment with low levels of rotenone caused gradual degeneration of the dopamine neurons in rats, and reproduced many of the features of Parkinsonism.
In the new study, the Emory scientists exposed human neuroblastoma cells to the pesticides rotenone, pyridaben, fenazaquin, and fenpyroximate, all of which inhibit complex I. Pyridaben was by far the most potent toxic compound, followed by rotenone and fenpyroximate, with fenazaquin being the least toxic. Pyridaben was also more potent than rotenone in producing "free radicals" and oxidative damage to the cells, both of which are thought to be important in causing Parkinsons disease.
Holly Korschun | EurekAlert!
A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich
New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
20.02.2017 | Materials Sciences
20.02.2017 | Health and Medicine
20.02.2017 | Health and Medicine