Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Several commonly used pesticides are toxic to mitochondria in laboratory experiments

10.11.2003


Pesticides attack same cellular targets as rotenone - already implicated in Parkinson’s disease



Scientists at Emory University School of Medicine have found in laboratory experiments that several commonly used pesticides are just as toxic or even more toxic to the mitochondria of cells than the pesticide rotenone, which already has been implicated in the development of Parkinson’s disease. The Emory neurologists, led by Tim Greenamyre, MD, PhD and Todd B. Sherer, PhD, will present the results of their comparative research with pesticides at the Society for Neuroscience meeting in New Orleans on Saturday, Nov. 8.
Parkinson’s disease, which is one of the most common neurodegenerative diseases, has been associated abnormalities of mitochondria, which are the "power plants" that provide all cells with energy. Rotenone and many other pesticides are known to damage the mitochondria by inhibiting a mitochondrial enzyme called complex I. In earlier experiments, Dr. Greenamyre and his colleagues found that chronic treatment with low levels of rotenone caused gradual degeneration of the dopamine neurons in rats, and reproduced many of the features of Parkinsonism.

In the new study, the Emory scientists exposed human neuroblastoma cells to the pesticides rotenone, pyridaben, fenazaquin, and fenpyroximate, all of which inhibit complex I. Pyridaben was by far the most potent toxic compound, followed by rotenone and fenpyroximate, with fenazaquin being the least toxic. Pyridaben was also more potent than rotenone in producing "free radicals" and oxidative damage to the cells, both of which are thought to be important in causing Parkinson’s disease.



"These results show that commonly used pesticides are toxic to cells, and may cause the kinds of cellular damage that lead to diseases such as Parkinson’s," Dr. Sherer says. "Although our study does not prove that any particular pesticide causes Parkinson’s, it does lead to more questions about the safety of chronic exposure to these environmental agents and certainly warrants additional research." Last year Emory created a new Emory Collaborative Center for Parkinson’s Disease Environmental Research through a grant of more than $6.5 million from the National Institute of Environmental Health Sciences.

"For quite a while scientists have believed that environmental factors, including pesticides, may be important in causing Parkinson’s disease," Dr. Greenamyre says. "We are continuing our research to determine exactly how these exposures cause nerve cell damage and death."

Other Emory scientists involved in the research study were Gary W. Miller, PhD, associate professor in Emory’s Rollins School of Public Health, and neurologists Alexander Panov, PhD and Jason Richardson, PhD.

Holly Korschun | EurekAlert!
Further information:
http://www.emory.edu/

More articles from Life Sciences:

nachricht First-of-its-kind chemical oscillator offers new level of molecular control
15.12.2017 | University of Texas at Austin

nachricht New technique could make captured carbon more valuable
15.12.2017 | DOE/Idaho National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

New technique could make captured carbon more valuable

15.12.2017 | Life Sciences

First-of-its-kind chemical oscillator offers new level of molecular control

15.12.2017 | Life Sciences

A chip for environmental and health monitoring

15.12.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>