Dr Antonio Giordano, director of the Sbarro Institute for Cancer Research and Molecular Medicine based at Temple University.
Photo Credit: Joseph V. Labolito
The molecular mechanisms that may assist the tumor suppressing gene Rb2/p130 in blocking the progression of lung cancer cells has been clearly identified for the first time according to a study by researchers at Temple University’s Sbarro Institute for Cancer Research and Molecular Medicine.
The results of their study, "pRb2/p130 target genes in non-small cell lung cancer cells identified by microarray analysis," appear in the Oct. 9 issue of Oncogene (http://www.nature.com/onc/).
The study, led by Antonio Giordano, M.D., Ph.D., head of the Sbarro Institute at Temple, was a follow-up to previous experiments led by Giordano that demonstrated an inverse relationship between Rb2 expression and the aggressiveness of lung cancer. Giordano discovered the Rb2 gene while working at Temple’s Fels Cancer Institute in the early 1990s. In those earlier studies, correct copies of Rb2 were introduced into mice with lung tumors using a viral system developed by Pier Paolo Claudio, M.D., Ph.D., associate professor of biotechnology at the Sbarro Institute. When the Rb2 gene was over-expressed in the cancer cells, it caused the tumors in the mice to completely regress(http://jncicancerspectrum.oupjournals.org/jnci/content/vol90/issue19).
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