Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tufts University bioengineers discover secret of spider, silkworm fiber strength

28.08.2003


Findings could drive new tissue engineering applications, organ repair and high-strength materials



Tufts University bioengineers have discovered how spiders and silkworms are able to spin webs and cocoons made of incredibly strong fibers. The answer lies in how they control the silk protein solubility and structural organization in their glands.

"This finding could lead to the development of processing methods resulting in new high-strength and high-performance materials used for biomedical applications, and protective apparel for military and police forces," said David Kaplan, professor and chair of biomedical engineering, and director of Tufts’ Bioengineering Center.


"We identified key aspects of the process that should provide a roadmap for others to optimize artificial spinning of silks as well as in improved production of silks in genetically engineered host systems such as bacteria and transgenic animals," said Kaplan, also a professor of chemical and biological engineering.

He and former postdoctoral fellow Hyoung-Joon Jin published their findings, "Mechanism of Processing of Silks in Insects and Spiders," in the Aug. 28 issue of the international science journal Nature.

The research was funded with $1 million from the National Institutes of Health Dental Institute and $200,000 from the U.S. Air Force Office of Scientific Research. Kaplan collaborated with Tufts colleagues across the University – from chemical, biological and biomedical to the veterinary and dental schools.

Silk is the strongest natural fiber known, but its strength has yet to be replicated in a laboratory. One reason may be the previous lack of understanding how spiders and silkworm process the silk.

The Tufts team has identified the way that spiders and silkworms control the solubility, concentration and structure of the proteins in their glands that spin the silk.

According to Kaplan, silk proteins are organized into pseudo-micelle or soap-like structures that form globular and gel states during processing in the glands. This semi-stable state, with sufficiently entrapped water and liquid crystalline structures, prevents the proteins from crystallizing too early, until the spinning process.

The structures formed in the process can be easily converted artificially into fibers with physical shear (moving the silk gel between two plates of glass) or during fiber spinning in the native process. The control of water content and structure development are essential because premature crystallization of the protein could cause a permanent blockage of the spinning system, leading to catastrophic consequences for the spider or silkworm.

This process, when combined with the novel polymer design features in silk proteins, retains sufficient water to keep the protein soluble, while allowing the protein to self-organize and reach spinnable concentrations. Achieving sufficient concentration of protein is key to the proper spinning of fibers and to the spider’s and silkworm’s survival.

Kaplan says this new insight into silk processing could result in:


New high-strength and high-performance materials such as sports equipment, hiking gear and protective clothing for law enforcement;

New biomaterial applications for cell growth in tissue engineering, as well as general biomaterial needs for tissue and organ repair;

Environmentally sound processes to generate fibers and films from these types of polymers, since the entire process occurs in water.
"Kaplan’s research is distinctive because it addresses a fundamental problem common to all prior research in this field," said Jamshed Bharucha, Tufts provost and senior vice president.

In 2002, Kaplan and his team of researchers from Tufts’ schools of engineering and medicine developed a tissue engineering strategy to repair one of the world’s most common knee injuries -- ruptured anterior cruciate ligaments (ACL) -- by mechanically and biologically engineering new ones using silk scaffolding for cell growth. This ligament at the center of the knee connects the leg to the thigh and stabilizes the knee joint in leg extension and flexion.

Approximately 200,000 ACL surgeries were done in the U.S. in 2001, costing an estimated $3.5 billion, plus another $200 million for subsequent therapy. The costs associated with surgery can range from $10,000 to $25,000 per procedure, and up to $1,200 in physical therapy.


Tufts University, located on three Massachusetts campuses in Boston, Medford/Somerville, and Grafton, and in Talloires, France, is recognized among the premier research universities in the United States. Tufts enjoys a global reputation for academic excellence and for the preparation of students as leaders in a wide range of professions. A growing number of innovative teaching and research initiatives span all Tufts campuses, and collaboration among the faculty and students in the undergraduate, graduate and professional programs across the University’s eight schools is widely encouraged.


Craig LeMoult | EurekAlert!
Further information:
http://www.tufts.edu/

More articles from Life Sciences:

nachricht New switch decides between genome repair and death of cells
27.09.2016 | University of Cologne - Universität zu Köln

nachricht A blue stoplight to prevent runaway photosynthesis
27.09.2016 | National Institute for Basic Biology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New welding process joins dissimilar sheets better

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

European Health Forum Gastein 2016 kicks off today

28.09.2016 | Event News

Laser use for neurosurgery and biofabrication - LaserForum 2016 focuses on medical technology

27.09.2016 | Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

 
Latest News

New imaging technique in Alzheimer’s disease - opens up possibilities for new drug development

28.09.2016 | Medical Engineering

Innovate coating extends the life of materials for industrial use

28.09.2016 | Materials Sciences

Blockchain Set to Transform the Financial Services Market

28.09.2016 | Business and Finance

VideoLinks
B2B-VideoLinks
More VideoLinks >>>